TY  - JOUR
AU  - Antonenko, Daria
AU  - Fromm, Anna Elisabeth
AU  - Thams, Friederike
AU  - Kuzmina, Anna
AU  - Backhaus, Malte
AU  - Knochenhauer, Elena
AU  - Li, Shu-Chen
AU  - Grittner, Ulrike
AU  - Flöel, Agnes
TI  - Cognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial.
JO  - Alzheimer's research & therapy
VL  - 16
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DZNE-2024-00062
SP  - 6
PY  - 2024
AB  - Repeated sessions of training and non-invasive brain stimulation have the potential to enhance cognition in patients with cognitive impairment. We hypothesized that combining cognitive training with anodal transcranial direct current stimulation (tDCS) will lead to performance improvement in the trained task and yield transfer to non-trained tasks.In our randomized, sham-controlled, double-blind study, 46 patients with cognitive impairment (60-80 years) were randomly assigned to one of two interventional groups. We administered a 9-session cognitive training (consisting of a letter updating and a Markov decision-making task) over 3 weeks with concurrent 1-mA anodal tDCS over the left dorsolateral prefrontal cortex (20 min in tDCS, 30 s in sham group). Primary outcome was trained task performance (letter updating task) immediately after training. Secondary outcomes included performance in tasks testing working memory (N-back task), decision-making (Wiener Matrices test) and verbal memory (verbal learning and memory test), and resting-state functional connectivity (FC). Tasks were administered at baseline, at post-assessment, and at 1- and 7-month follow-ups (FU). MRI was conducted at baseline and 7-month FU. Thirty-nine participants (85
KW  - Humans
KW  - Transcranial Direct Current Stimulation: methods
KW  - Cognitive Training
KW  - Memory, Short-Term: physiology
KW  - Cognitive Dysfunction: therapy
KW  - Double-Blind Method
KW  - Brain
KW  - Prefrontal Cortex
KW  - Electric field simulation (Other)
KW  - Mild cognitive impairment (Other)
KW  - Resting-state functional connectivity (Other)
KW  - Subjective cognitive decline (Other)
KW  - Transcranial direct current stimulation (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10782634
C6  - pmid:38212815
DO  - DOI:10.1186/s13195-024-01381-3
UR  - https://pub.dzne.de/record/267053
ER  -