%0 Journal Article
%A Fang, Lei
%A Zhang, Bo
%A Li, Bingxuan
%A Zhang, Xiangsong
%A Zhou, Xiaoyun
%A Yang, Jigang
%A Li, Ang
%A Shi, Xinchong
%A Liu, Yuqing
%A Kreißl, Michael
%A D'Ascenzo, Nicola
%A Xiao, Peng
%A Xie, Qingguo
%T Development and evaluation of a new high-TOF-resolution all-digital brain PET system.
%J Physics in medicine and biology
%V 69
%N 2
%@ 0031-9155
%C Bristol
%I IOP Publ.
%M DZNE-2024-00070
%P 025019
%D 2024
%X Objective.Time-of-flight (TOF) capability and high sensitivity are essential for brain-dedicated positron emission tomography (PET) imaging, as they improve the contrast and the signal-to-noise ratio (SNR) enabling a precise localization of functional mechanisms in the different brain regions.Approach.We present a new brain PET system with transverse and axial field-of-view (FOV) of 320 mm and 255 mm, respectively. The system head is an array of 6 × 6 detection elements, each consisting of a 3.9 × 3.9 × 20 mm3lutetium-yttrium oxyorthosilicate crystal coupled with a 3.93 × 3.93 mm2SiPM. The SiPMs analog signals are individually digitized using the multi-voltage threshold (MVT) technology, employing a 1:1:1 coupling configuration.Main results.The brain PET system exhibits a TOF resolution of 249 ps at 5.3 kBq ml-1, an average sensitivity of 22.1 cps kBq-1, and a noise equivalent count rate (NECR) peak of 150.9 kcps at 8.36 kBq ml-1. Furthermore, the mini-Derenzo phantom study demonstrated the system's ability to distinguish rods with a diameter of 2.0 mm. Moreover, incorporating the TOF reconstruction algorithm in an image quality phantom study optimizes the background variability, resulting in reductions ranging from 44
%K Humans
%K Positron-Emission Tomography: methods
%K Brain: diagnostic imaging
%K Signal-To-Noise Ratio
%K Phantoms, Imaging
%K Lutetium
%K Silicates
%K 249 ps (Other)
%K Brain PET (Other)
%K MVT sampling method (Other)
%K TOF (Other)
%K lutetium orthosilicate (NLM Chemicals)
%K Lutetium (NLM Chemicals)
%K Silicates (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38100841
%R 10.1088/1361-6560/ad164d
%U https://pub.dzne.de/record/267061