TY  - JOUR
AU  - Fang, Lei
AU  - Zhang, Bo
AU  - Li, Bingxuan
AU  - Zhang, Xiangsong
AU  - Zhou, Xiaoyun
AU  - Yang, Jigang
AU  - Li, Ang
AU  - Shi, Xinchong
AU  - Liu, Yuqing
AU  - Kreißl, Michael
AU  - D'Ascenzo, Nicola
AU  - Xiao, Peng
AU  - Xie, Qingguo
TI  - Development and evaluation of a new high-TOF-resolution all-digital brain PET system.
JO  - Physics in medicine and biology
VL  - 69
IS  - 2
SN  - 0031-9155
CY  - Bristol
PB  - IOP Publ.
M1  - DZNE-2024-00070
SP  - 025019
PY  - 2024
AB  - Objective.Time-of-flight (TOF) capability and high sensitivity are essential for brain-dedicated positron emission tomography (PET) imaging, as they improve the contrast and the signal-to-noise ratio (SNR) enabling a precise localization of functional mechanisms in the different brain regions.Approach.We present a new brain PET system with transverse and axial field-of-view (FOV) of 320 mm and 255 mm, respectively. The system head is an array of 6 × 6 detection elements, each consisting of a 3.9 × 3.9 × 20 mm3lutetium-yttrium oxyorthosilicate crystal coupled with a 3.93 × 3.93 mm2SiPM. The SiPMs analog signals are individually digitized using the multi-voltage threshold (MVT) technology, employing a 1:1:1 coupling configuration.Main results.The brain PET system exhibits a TOF resolution of 249 ps at 5.3 kBq ml-1, an average sensitivity of 22.1 cps kBq-1, and a noise equivalent count rate (NECR) peak of 150.9 kcps at 8.36 kBq ml-1. Furthermore, the mini-Derenzo phantom study demonstrated the system's ability to distinguish rods with a diameter of 2.0 mm. Moreover, incorporating the TOF reconstruction algorithm in an image quality phantom study optimizes the background variability, resulting in reductions ranging from 44
KW  - Humans
KW  - Positron-Emission Tomography: methods
KW  - Brain: diagnostic imaging
KW  - Signal-To-Noise Ratio
KW  - Phantoms, Imaging
KW  - Lutetium
KW  - Silicates
KW  - 249 ps (Other)
KW  - Brain PET (Other)
KW  - MVT sampling method (Other)
KW  - TOF (Other)
KW  - lutetium orthosilicate (NLM Chemicals)
KW  - Lutetium (NLM Chemicals)
KW  - Silicates (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38100841
DO  - DOI:10.1088/1361-6560/ad164d
UR  - https://pub.dzne.de/record/267061
ER  -