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001     267061
005     20240403131600.0
024 7 _ |a 10.1088/1361-6560/ad164d
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024 7 _ |a 1361-6560
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037 _ _ |a DZNE-2024-00070
041 _ _ |a English
082 _ _ |a 530
100 1 _ |a Fang, Lei
|b 0
245 _ _ |a Development and evaluation of a new high-TOF-resolution all-digital brain PET system.
260 _ _ |a Bristol
|c 2024
|b IOP Publ.
336 7 _ |a article
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520 _ _ |a Objective.Time-of-flight (TOF) capability and high sensitivity are essential for brain-dedicated positron emission tomography (PET) imaging, as they improve the contrast and the signal-to-noise ratio (SNR) enabling a precise localization of functional mechanisms in the different brain regions.Approach.We present a new brain PET system with transverse and axial field-of-view (FOV) of 320 mm and 255 mm, respectively. The system head is an array of 6 × 6 detection elements, each consisting of a 3.9 × 3.9 × 20 mm3lutetium-yttrium oxyorthosilicate crystal coupled with a 3.93 × 3.93 mm2SiPM. The SiPMs analog signals are individually digitized using the multi-voltage threshold (MVT) technology, employing a 1:1:1 coupling configuration.Main results.The brain PET system exhibits a TOF resolution of 249 ps at 5.3 kBq ml-1, an average sensitivity of 22.1 cps kBq-1, and a noise equivalent count rate (NECR) peak of 150.9 kcps at 8.36 kBq ml-1. Furthermore, the mini-Derenzo phantom study demonstrated the system's ability to distinguish rods with a diameter of 2.0 mm. Moreover, incorporating the TOF reconstruction algorithm in an image quality phantom study optimizes the background variability, resulting in reductions ranging from 44% (37 mm) to 75% (10 mm) with comparable contrast. In the human brain imaging study, the SNR improved by a factor of 1.7 with the inclusion of TOF, increasing from 27.07 to 46.05. Time-dynamic human brain imaging was performed, showing the distinctive traits of cortex and thalamus uptake, as well as of the arterial and venous flow with 2 s per time frame.Significance.The system exhibited a good TOF capability, which is coupled with the high sensitivity and count rate performance based on the MVT digital sampling technique. The developed TOF-enabled brain PET system opens the possibility of precise kinetic brain PET imaging, towards new quantitative predictive brain diagnostics.
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650 _ 7 |a 249 ps
|2 Other
650 _ 7 |a Brain PET
|2 Other
650 _ 7 |a MVT sampling method
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650 _ 7 |a TOF
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650 _ 7 |a lutetium orthosilicate
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650 _ 7 |a Lutetium
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650 _ 7 |a Silicates
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Positron-Emission Tomography: methods
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Signal-To-Noise Ratio
|2 MeSH
650 _ 2 |a Phantoms, Imaging
|2 MeSH
650 _ 2 |a Lutetium
|2 MeSH
650 _ 2 |a Silicates
|2 MeSH
700 1 _ |a Zhang, Bo
|b 1
700 1 _ |a Li, Bingxuan
|b 2
700 1 _ |a Zhang, Xiangsong
|b 3
700 1 _ |a Zhou, Xiaoyun
|b 4
700 1 _ |a Yang, Jigang
|b 5
700 1 _ |a Li, Ang
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700 1 _ |a Shi, Xinchong
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700 1 _ |a Liu, Yuqing
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700 1 _ |a Kreißl, Michael
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700 1 _ |a D'Ascenzo, Nicola
|0 0000-0002-3657-3607
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700 1 _ |a Xiao, Peng
|b 11
700 1 _ |a Xie, Qingguo
|b 12
773 _ _ |a 10.1088/1361-6560/ad164d
|g Vol. 69, no. 2, p. 025019 -
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|t Physics in medicine and biology
|v 69
|y 2024
|x 0031-9155
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