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000267348 1001_ $$aNespoli, Ester$$b0
000267348 245__ $$aGlial cells react to closed head injury in a distinct and spatiotemporally orchestrated manner.
000267348 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2024
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000267348 520__ $$aTraumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Acute neuroinflammation is a prominent reaction after TBI and is mostly initiated by brain-resident glial cells such as microglia, NG2-glia and astrocytes. The magnitude of this reaction paves the way for long-lasting consequences such as chronic neurological pathologies, for which therapeutic options remain limited. The neuroinflammatory response to TBI is mostly studied with craniotomy-based animal models that are very robust but also rather artificial. Here, we aimed to analyze the reaction of glial cells in a highly translational but variable closed head injury (CHI) model and were able to correlate the severity of the trauma to the degree of glial response. Furthermore, we could show that the different glial cell types react in a temporally and spatially orchestrated manner in terms of morphological changes, proliferation, and cell numbers in the first 15 days after the lesion. Interestingly, NG2-glia, the only proliferating cells in the healthy brain parenchyma, divided at a rate that was correlated with the size of the injury. Our findings describe the previously uncharacterized posttraumatic response of the major brain glial cell types in CHI in order to gain a detailed understanding of the course of neuroinflammatory events; such knowledge may open novel avenues for future therapeutic approaches in TBI.
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000267348 650_2 $$2MeSH$$aAnimals
000267348 650_2 $$2MeSH$$aNeuroglia: metabolism
000267348 650_2 $$2MeSH$$aBrain: metabolism
000267348 650_2 $$2MeSH$$aBrain Injuries, Traumatic: pathology
000267348 650_2 $$2MeSH$$aAstrocytes: metabolism
000267348 650_2 $$2MeSH$$aMicroglia: metabolism
000267348 650_2 $$2MeSH$$aHead Injuries, Closed: pathology
000267348 650_2 $$2MeSH$$aDisease Models, Animal
000267348 7001_ $$aHakani, Marsela$$b1
000267348 7001_ $$aHein, Tabea Melissa$$b2
000267348 7001_ $$aMay, Stephanie Nadine$$b3
000267348 7001_ $$0P:(DE-2719)9001513$$aDanzer, Karin$$b4$$udzne
000267348 7001_ $$aWirth, Thomas$$b5
000267348 7001_ $$aBaumann, Bernd$$b6
000267348 7001_ $$00000-0002-7818-4407$$aDimou, Leda$$b7
000267348 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-024-52337-4$$gVol. 14, no. 1, p. 2441$$n1$$p2441$$tScientific reports$$v14$$x2045-2322$$y2024
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