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@ARTICLE{Rayamajhi:267357,
      author       = {Rayamajhi, Dheeraj and Ege, Mert and Ukhanov, Kirill and
                      Ringers, Christa and Zhang, Yiliu and Jung, Inyoung and
                      D'Gama, Percival P and Li, Summer Shijia and Cosacak, Mehmet
                      Ilyas and Kizil, Caghan and Park, Hae-Chul and Yaksi, Emre
                      and Martens, Jeffrey R and Brody, Steven L and
                      Jurisch-Yaksi, Nathalie and Roy, Sudipto},
      title        = {{T}he forkhead transcription factor {F}oxj1 controls
                      vertebrate olfactory cilia biogenesis and sensory neuron
                      differentiation.},
      journal      = {PLoS biology},
      volume       = {22},
      number       = {1},
      issn         = {1544-9173},
      address      = {Lawrence, KS},
      publisher    = {PLoS},
      reportid     = {DZNE-2024-00121},
      pages        = {e3002468},
      year         = {2024},
      abstract     = {In vertebrates, olfactory receptors localize on multiple
                      cilia elaborated on dendritic knobs of olfactory sensory
                      neurons (OSNs). Although olfactory cilia dysfunction can
                      cause anosmia, how their differentiation is programmed at
                      the transcriptional level has remained largely unexplored.
                      We discovered in zebrafish and mice that Foxj1, a forkhead
                      domain-containing transcription factor traditionally linked
                      with motile cilia biogenesis, is expressed in OSNs and
                      required for olfactory epithelium (OE) formation. In keeping
                      with the immotile nature of olfactory cilia, we observed
                      that ciliary motility genes are repressed in zebrafish,
                      mouse, and human OSNs. Strikingly, we also found that
                      besides ciliogenesis, Foxj1 controls the differentiation of
                      the OSNs themselves by regulating their cell type-specific
                      gene expression, such as that of olfactory marker protein
                      (omp) involved in odor-evoked signal transduction. In line
                      with this, response to bile acids, odors detected by
                      OMP-positive OSNs, was significantly diminished in foxj1
                      mutant zebrafish. Taken together, our findings establish how
                      the canonical Foxj1-mediated motile ciliogenic
                      transcriptional program has been repurposed for the
                      biogenesis of immotile olfactory cilia, as well as for the
                      development of the OSNs.},
      keywords     = {Animals / Humans / Mice / Zebrafish: genetics / Zebrafish:
                      metabolism / Cilia: metabolism / Forkhead Transcription
                      Factors: genetics / Forkhead Transcription Factors:
                      metabolism / Olfactory Receptor Neurons / Olfactory Mucosa /
                      Forkhead Transcription Factors (NLM Chemicals)},
      cin          = {AG Kizil},
      ddc          = {610},
      cid          = {I:(DE-2719)1710007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38271330},
      pmc          = {pmc:PMC10810531},
      doi          = {10.1371/journal.pbio.3002468},
      url          = {https://pub.dzne.de/record/267357},
}