guest ::
| Home > Publications Database > The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. > print |
| Home > Publications Database > The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. > print |
| 001 | 267357 | ||
| 005 | 20240403131601.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pbio.3002468 |2 doi |
| 024 | 7 | _ | |a pmid:38271330 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC10810531 |2 pmc |
| 024 | 7 | _ | |a 1544-9173 |2 ISSN |
| 024 | 7 | _ | |a 1545-7885 |2 ISSN |
| 024 | 7 | _ | |a altmetric:158750433 |2 altmetric |
| 037 | _ | _ | |a DZNE-2024-00121 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Rayamajhi, Dheeraj |b 0 |
| 245 | _ | _ | |a The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. |
| 260 | _ | _ | |a Lawrence, KS |c 2024 |b PLoS |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1707816246_13997 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a In vertebrates, olfactory receptors localize on multiple cilia elaborated on dendritic knobs of olfactory sensory neurons (OSNs). Although olfactory cilia dysfunction can cause anosmia, how their differentiation is programmed at the transcriptional level has remained largely unexplored. We discovered in zebrafish and mice that Foxj1, a forkhead domain-containing transcription factor traditionally linked with motile cilia biogenesis, is expressed in OSNs and required for olfactory epithelium (OE) formation. In keeping with the immotile nature of olfactory cilia, we observed that ciliary motility genes are repressed in zebrafish, mouse, and human OSNs. Strikingly, we also found that besides ciliogenesis, Foxj1 controls the differentiation of the OSNs themselves by regulating their cell type-specific gene expression, such as that of olfactory marker protein (omp) involved in odor-evoked signal transduction. In line with this, response to bile acids, odors detected by OMP-positive OSNs, was significantly diminished in foxj1 mutant zebrafish. Taken together, our findings establish how the canonical Foxj1-mediated motile ciliogenic transcriptional program has been repurposed for the biogenesis of immotile olfactory cilia, as well as for the development of the OSNs. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Forkhead Transcription Factors |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Zebrafish: genetics |2 MeSH |
| 650 | _ | 2 | |a Zebrafish: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cilia: metabolism |2 MeSH |
| 650 | _ | 2 | |a Forkhead Transcription Factors: genetics |2 MeSH |
| 650 | _ | 2 | |a Forkhead Transcription Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Olfactory Receptor Neurons |2 MeSH |
| 650 | _ | 2 | |a Olfactory Mucosa |2 MeSH |
| 700 | 1 | _ | |a Ege, Mert |b 1 |
| 700 | 1 | _ | |a Ukhanov, Kirill |b 2 |
| 700 | 1 | _ | |a Ringers, Christa |b 3 |
| 700 | 1 | _ | |a Zhang, Yiliu |b 4 |
| 700 | 1 | _ | |a Jung, Inyoung |b 5 |
| 700 | 1 | _ | |a D'Gama, Percival P |b 6 |
| 700 | 1 | _ | |a Li, Summer Shijia |b 7 |
| 700 | 1 | _ | |a Cosacak, Mehmet Ilyas |0 P:(DE-2719)2811286 |b 8 |u dzne |
| 700 | 1 | _ | |a Kizil, Caghan |0 P:(DE-2719)2811030 |b 9 |u dzne |
| 700 | 1 | _ | |a Park, Hae-Chul |b 10 |
| 700 | 1 | _ | |a Yaksi, Emre |b 11 |
| 700 | 1 | _ | |a Martens, Jeffrey R |b 12 |
| 700 | 1 | _ | |a Brody, Steven L |b 13 |
| 700 | 1 | _ | |a Jurisch-Yaksi, Nathalie |b 14 |
| 700 | 1 | _ | |a Roy, Sudipto |0 0000-0002-6636-1429 |b 15 |
| 773 | _ | _ | |a 10.1371/journal.pbio.3002468 |g Vol. 22, no. 1, p. e3002468 - |0 PERI:(DE-600)2126773-X |n 1 |p e3002468 |t PLoS biology |v 22 |y 2024 |x 1544-9173 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/267357/files/DZNE-2024-00121.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/267357/files/DZNE-2024-00121.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:267357 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)2811286 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 9 |6 P:(DE-2719)2811030 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 0 |
| 914 | 1 | _ | |y 2024 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2022-01-10T10:28:08Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-08-24 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2023-08-24 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-08-24 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b PLOS BIOL : 2022 |d 2023-08-24 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-08-24 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b PLOS BIOL : 2022 |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2022-01-10T10:28:08Z |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2023-08-24 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-08-24 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |d 2023-08-24 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Anonymous peer review |d 2022-01-10T10:28:08Z |
| 920 | 1 | _ | |0 I:(DE-2719)1710007 |k AG Kizil |l Mechanisms of Induced Plasticity of the Vertebrate Brain |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1710007 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|