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000267496 037__ $$aDZNE-2024-00142
000267496 041__ $$aEnglish
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000267496 1001_ $$00000-0002-3216-8452$$aObrecht-Sturm, Denise$$b0
000267496 245__ $$aPineal anlage tumor: clinical and diagnostic features, and rationales for treatment.
000267496 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2024
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000267496 520__ $$aTo provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).Prospectively collected data of three patients with pineal anlage tumor from Germany was combined with clinical details and treatment information from 17 published cases.Overall, 20 cases of PAT were identified (3 not previously reported German cases, 17 cases from published reports). Age at diagnosis ranged from 0.3 to 35.0 (median: 3.2 ± 7.8) years. All but three cases were diagnosed before the age of three years. For three cases, metastatic disease at initial staging was described. All patients underwent tumor surgery (gross-total resection: 9, subtotal resection/biopsy: 9, extent of resection unknown: 2). 15/20 patients were alive at last follow-up. Median follow-up for 10/15 surviving patients with available follow-up and treatment data was 2.4 years (0.3-6.5). Relapse was reported for 3 patients within 0.8 years after diagnosis. Five patients died, 3 after relapse and 2 from early postoperative complications. Two-year-progression-free- and -overall survival were 65.2 ± 12.7% and 49.2 ± 18.2%, respectively. All 4 patients who received intensive chemotherapy including high-dose chemotherapy combined with radiotherapy (2 focal, 2 craniospinal [CSI]) had no recurrence. Focal radiotherapy- and CSI-free survival rates in 13 evaluable patients were 46.2% (6/13) and 61.5% (8/13), respectively.PAT is an aggressive disease mostly affecting young children. Therefore, adjuvant therapy using intensive chemotherapy and considering radiotherapy appears to comprise an appropriate treatment strategy. Reporting further cases is crucial to evaluate distinct treatment strategies.
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000267496 650_7 $$2Other$$aPINEAL anlage tumor
000267496 650_7 $$2Other$$aPineal gland
000267496 650_7 $$2Other$$aPineoblastoma
000267496 650_2 $$2MeSH$$aChild
000267496 650_2 $$2MeSH$$aHumans
000267496 650_2 $$2MeSH$$aChild, Preschool
000267496 650_2 $$2MeSH$$aInfant
000267496 650_2 $$2MeSH$$aAdolescent
000267496 650_2 $$2MeSH$$aYoung Adult
000267496 650_2 $$2MeSH$$aAdult
000267496 650_2 $$2MeSH$$aTreatment Outcome
000267496 650_2 $$2MeSH$$aPineal Gland: surgery
000267496 650_2 $$2MeSH$$aPineal Gland: pathology
000267496 650_2 $$2MeSH$$aNeoplasm Recurrence, Local: pathology
000267496 650_2 $$2MeSH$$aPinealoma: diagnosis
000267496 650_2 $$2MeSH$$aPinealoma: surgery
000267496 650_2 $$2MeSH$$aSupratentorial Neoplasms: pathology
000267496 650_2 $$2MeSH$$aBrain Neoplasms: diagnosis
000267496 650_2 $$2MeSH$$aBrain Neoplasms: surgery
000267496 650_2 $$2MeSH$$aRecurrence
000267496 7001_ $$aPfaff, Elke$$b1
000267496 7001_ $$aMynarek, Martin$$b2
000267496 7001_ $$aBison, Brigitte$$b3
000267496 7001_ $$aRodehüser, Martina$$b4
000267496 7001_ $$aBecker, Martina$$b5
000267496 7001_ $$aKietz, Silke$$b6
000267496 7001_ $$aPfister, Stefan M$$b7
000267496 7001_ $$aJones, David T$$b8
000267496 7001_ $$aSturm, Dominik$$b9
000267496 7001_ $$avon Deimling, Andreas$$b10
000267496 7001_ $$aSahm, Felix$$b11
000267496 7001_ $$aKortmann, Rolf-Dieter$$b12
000267496 7001_ $$aSchwarz, Rudolf$$b13
000267496 7001_ $$0P:(DE-2719)2812617$$aPietsch, Torsten$$b14$$udzne
000267496 7001_ $$aFleischhack, Gudrun$$b15
000267496 7001_ $$aRutkowski, Stefan$$b16
000267496 773__ $$0PERI:(DE-600)2007293-4$$a10.1007/s11060-023-04547-5$$gVol. 166, no. 2, p. 359 - 368$$n2$$p359 - 368$$tJournal of neuro-oncology$$v166$$x0167-594X$$y2024
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