TY  - JOUR
AU  - Obrecht-Sturm, Denise
AU  - Pfaff, Elke
AU  - Mynarek, Martin
AU  - Bison, Brigitte
AU  - Rodehüser, Martina
AU  - Becker, Martina
AU  - Kietz, Silke
AU  - Pfister, Stefan M
AU  - Jones, David T
AU  - Sturm, Dominik
AU  - von Deimling, Andreas
AU  - Sahm, Felix
AU  - Kortmann, Rolf-Dieter
AU  - Schwarz, Rudolf
AU  - Pietsch, Torsten
AU  - Fleischhack, Gudrun
AU  - Rutkowski, Stefan
TI  - Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment.
JO  - Journal of neuro-oncology
VL  - 166
IS  - 2
SN  - 0167-594X
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DZNE-2024-00142
SP  - 359 - 368
PY  - 2024
AB  - To provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).Prospectively collected data of three patients with pineal anlage tumor from Germany was combined with clinical details and treatment information from 17 published cases.Overall, 20 cases of PAT were identified (3 not previously reported German cases, 17 cases from published reports). Age at diagnosis ranged from 0.3 to 35.0 (median: 3.2 ± 7.8) years. All but three cases were diagnosed before the age of three years. For three cases, metastatic disease at initial staging was described. All patients underwent tumor surgery (gross-total resection: 9, subtotal resection/biopsy: 9, extent of resection unknown: 2). 15/20 patients were alive at last follow-up. Median follow-up for 10/15 surviving patients with available follow-up and treatment data was 2.4 years (0.3-6.5). Relapse was reported for 3 patients within 0.8 years after diagnosis. Five patients died, 3 after relapse and 2 from early postoperative complications. Two-year-progression-free- and -overall survival were 65.2 ± 12.7
KW  - Child
KW  - Humans
KW  - Child, Preschool
KW  - Infant
KW  - Adolescent
KW  - Young Adult
KW  - Adult
KW  - Treatment Outcome
KW  - Pineal Gland: surgery
KW  - Pineal Gland: pathology
KW  - Neoplasm Recurrence, Local: pathology
KW  - Pinealoma: diagnosis
KW  - Pinealoma: surgery
KW  - Supratentorial Neoplasms: pathology
KW  - Brain Neoplasms: diagnosis
KW  - Brain Neoplasms: surgery
KW  - Recurrence
KW  - PINEAL anlage tumor (Other)
KW  - Pineal gland (Other)
KW  - Pineoblastoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38253790
C2  - pmc:PMC10834633
DO  - DOI:10.1007/s11060-023-04547-5
UR  - https://pub.dzne.de/record/267496
ER  -