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@ARTICLE{ObrechtSturm:267496,
      author       = {Obrecht-Sturm, Denise and Pfaff, Elke and Mynarek, Martin
                      and Bison, Brigitte and Rodehüser, Martina and Becker,
                      Martina and Kietz, Silke and Pfister, Stefan M and Jones,
                      David T and Sturm, Dominik and von Deimling, Andreas and
                      Sahm, Felix and Kortmann, Rolf-Dieter and Schwarz, Rudolf
                      and Pietsch, Torsten and Fleischhack, Gudrun and Rutkowski,
                      Stefan},
      title        = {{P}ineal anlage tumor: clinical and diagnostic features,
                      and rationales for treatment.},
      journal      = {Journal of neuro-oncology},
      volume       = {166},
      number       = {2},
      issn         = {0167-594X},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DZNE-2024-00142},
      pages        = {359 - 368},
      year         = {2024},
      abstract     = {To provide a treatment-focused review and develop basic
                      treatment guidelines for patients diagnosed with pineal
                      anlage tumor (PAT).Prospectively collected data of three
                      patients with pineal anlage tumor from Germany was combined
                      with clinical details and treatment information from 17
                      published cases.Overall, 20 cases of PAT were identified (3
                      not previously reported German cases, 17 cases from
                      published reports). Age at diagnosis ranged from 0.3 to 35.0
                      (median: 3.2 ± 7.8) years. All but three cases were
                      diagnosed before the age of three years. For three cases,
                      metastatic disease at initial staging was described. All
                      patients underwent tumor surgery (gross-total resection: 9,
                      subtotal resection/biopsy: 9, extent of resection unknown:
                      2). 15/20 patients were alive at last follow-up. Median
                      follow-up for 10/15 surviving patients with available
                      follow-up and treatment data was 2.4 years (0.3-6.5).
                      Relapse was reported for 3 patients within 0.8 years after
                      diagnosis. Five patients died, 3 after relapse and 2 from
                      early postoperative complications.
                      Two-year-progression-free- and -overall survival were 65.2
                      ± $12.7\%$ and 49.2 ± $18.2\%,$ respectively. All 4
                      patients who received intensive chemotherapy including
                      high-dose chemotherapy combined with radiotherapy (2 focal,
                      2 craniospinal [CSI]) had no recurrence. Focal radiotherapy-
                      and CSI-free survival rates in 13 evaluable patients were
                      $46.2\%$ (6/13) and $61.5\%$ (8/13), respectively.PAT is an
                      aggressive disease mostly affecting young children.
                      Therefore, adjuvant therapy using intensive chemotherapy and
                      considering radiotherapy appears to comprise an appropriate
                      treatment strategy. Reporting further cases is crucial to
                      evaluate distinct treatment strategies.},
      subtyp        = {Review Article},
      keywords     = {Child / Humans / Child, Preschool / Infant / Adolescent /
                      Young Adult / Adult / Treatment Outcome / Pineal Gland:
                      surgery / Pineal Gland: pathology / Neoplasm Recurrence,
                      Local: pathology / Pinealoma: diagnosis / Pinealoma: surgery
                      / Supratentorial Neoplasms: pathology / Brain Neoplasms:
                      diagnosis / Brain Neoplasms: surgery / Recurrence / PINEAL
                      anlage tumor (Other) / Pineal gland (Other) / Pineoblastoma
                      (Other)},
      cin          = {Brainbank Unit Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)1011009},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38253790},
      pmc          = {pmc:PMC10834633},
      doi          = {10.1007/s11060-023-04547-5},
      url          = {https://pub.dzne.de/record/267496},
}