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000267506 1001_ $$aOjeda-Alonso, Julia$$b0
000267506 245__ $$aSensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
000267506 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000267506 520__ $$aPrevious work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on sensory Schwann cells. In polymodal nociceptors, sensory Schwann cells signal mechanical, but not cold or heat pain. Terminal Schwann cells also surround mechanoreceptor nerve-endings within the Meissner's corpuscle and in hair follicle lanceolate endings that both signal vibrotactile touch. Within Meissner´s corpuscles, two molecularly and functionally distinct sensory Schwann cells positive for Sox10 and Sox2 differentially modulate rapidly adapting mechanoreceptor function. Using optogenetics we show that Meissner's corpuscle Schwann cells are necessary for the perception of low threshold vibrotactile stimuli. These results show that sensory Schwann cells within diverse glio-neural mechanosensory end-organs are sensors for mechanical pain as well as necessary for touch perception.
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000267506 650_2 $$2MeSH$$aMice
000267506 650_2 $$2MeSH$$aAnimals
000267506 650_2 $$2MeSH$$aTouch: physiology
000267506 650_2 $$2MeSH$$aNociception
000267506 650_2 $$2MeSH$$aTouch Perception: physiology
000267506 650_2 $$2MeSH$$aMechanoreceptors: physiology
000267506 650_2 $$2MeSH$$aSchwann Cells
000267506 650_2 $$2MeSH$$aPain
000267506 650_2 $$2MeSH$$aSensory Thresholds
000267506 7001_ $$00000-0002-9428-3974$$aCalvo-Enrique, Laura$$b1
000267506 7001_ $$0P:(DE-2719)9002046$$aMontesinos, Ricardo Paricio$$b2$$udzne
000267506 7001_ $$00000-0001-9693-4374$$aKumar, Rakesh$$b3
000267506 7001_ $$00000-0002-6348-1994$$aZhang, Ming-Dong$$b4
000267506 7001_ $$00000-0003-0296-5415$$aPoulet, James F A$$b5
000267506 7001_ $$00000-0002-1140-3986$$aErnfors, Patrik$$b6
000267506 7001_ $$00000-0002-2890-6352$$aLewin, Gary R$$b7
000267506 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-44845-8$$gVol. 15, no. 1, p. 898$$n1$$p898$$tNature Communications$$v15$$x2041-1723$$y2024
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