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@ARTICLE{OjedaAlonso:267506,
      author       = {Ojeda-Alonso, Julia and Calvo-Enrique, Laura and
                      Montesinos, Ricardo Paricio and Kumar, Rakesh and Zhang,
                      Ming-Dong and Poulet, James F A and Ernfors, Patrik and
                      Lewin, Gary R},
      title        = {{S}ensory {S}chwann cells set perceptual thresholds for
                      touch and selectively regulate mechanical nociception.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2024-00152},
      pages        = {898},
      year         = {2024},
      abstract     = {Previous work identified nociceptive Schwann cells that can
                      initiate pain. Consistent with the existence of inherently
                      mechanosensitive sensory Schwann cells, we found that in
                      mice, the mechanosensory function of almost all nociceptors,
                      including those signaling fast pain, were dependent on
                      sensory Schwann cells. In polymodal nociceptors, sensory
                      Schwann cells signal mechanical, but not cold or heat pain.
                      Terminal Schwann cells also surround mechanoreceptor
                      nerve-endings within the Meissner's corpuscle and in hair
                      follicle lanceolate endings that both signal vibrotactile
                      touch. Within Meissner´s corpuscles, two molecularly and
                      functionally distinct sensory Schwann cells positive for
                      Sox10 and Sox2 differentially modulate rapidly adapting
                      mechanoreceptor function. Using optogenetics we show that
                      Meissner's corpuscle Schwann cells are necessary for the
                      perception of low threshold vibrotactile stimuli. These
                      results show that sensory Schwann cells within diverse
                      glio-neural mechanosensory end-organs are sensors for
                      mechanical pain as well as necessary for touch perception.},
      keywords     = {Mice / Animals / Touch: physiology / Nociception / Touch
                      Perception: physiology / Mechanoreceptors: physiology /
                      Schwann Cells / Pain / Sensory Thresholds},
      cin          = {AG Gründemann},
      ddc          = {500},
      cid          = {I:(DE-2719)5000069},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10847425},
      pubmed       = {pmid:38320986},
      doi          = {10.1038/s41467-024-44845-8},
      url          = {https://pub.dzne.de/record/267506},
}