TY  - JOUR
AU  - Abdelhak, Ahmed
AU  - Antweiler, Kai
AU  - Kowarik, Markus C
AU  - Senel, Makbule
AU  - Havla, Joachim
AU  - Zettl, Uwe K
AU  - Kleiter, Ingo
AU  - Skripuletz, Thomas
AU  - Haarmann, Axel
AU  - Stahmann, Alexander
AU  - Huss, Andre
AU  - Gingele, Stefan
AU  - Krumbholz, Markus
AU  - Benkert, Pascal
AU  - Kuhle, Jens
AU  - Friede, Tim
AU  - Ludolph, Albert C
AU  - Ziemann, Ulf
AU  - Kümpfel, Tania
AU  - Tumani, Hayrettin
TI  - Serum glial fibrillary acidic protein and disability progression in progressive multiple sclerosis.
JO  - Annals of Clinical and Translational Neurology
VL  - 11
IS  - 2
SN  - 2328-9503
CY  - Chichester [u.a.]
PB  - Wiley
M1  - DZNE-2024-00182
SP  - 477 - 485
PY  - 2024
AB  - Progression prediction is a significant unmet need in people with progressive multiple sclerosis (pwPMS). Studies on glial fibrillary acidic protein (GFAP) have either been limited to single center with relapsing MS or were based solely on Expanded Disability Status Scale (EDSS), which limits its generalizability to state-of-the-art clinical settings and trials applying combined outcome parameters.Serum GFAP and NfL (neurofilament light chain) were investigated in EmBioProMS participants with primary (PP) or secondary progressive MS. Six months confirmed disability progression (CDP) was defined using combined outcome parameters (EDSS, timed-25-foot walk test (T25FW), and nine-hole-peg-test (9HPT)).243 subjects (135 PPMS, 108 SPMS, age 55.5, IQR [49.7-61.2], 135 female, median follow-up: 29.3 months [17.9-40.9]) were included. NfL (age-) and GFAP (age- and sex-) adjusted Z scores were higher in pwPMS compared to HC (p < 0.001 for both). 111 (32.8
KW  - Male
KW  - Humans
KW  - Female
KW  - Middle Aged
KW  - Multiple Sclerosis
KW  - Glial Fibrillary Acidic Protein
KW  - Intermediate Filaments
KW  - Biomarkers
KW  - Neoplasm Recurrence, Local
KW  - Multiple Sclerosis, Chronic Progressive: diagnosis
KW  - GFAP protein, human (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38111972
C2  - pmc:PMC10863922
DO  - DOI:10.1002/acn3.51969
UR  - https://pub.dzne.de/record/267914
ER  -