TY  - JOUR
AU  - Stockbauer, Anna
AU  - Beyer, Leonie
AU  - Huber, Maria
AU  - Kreuzer, Annika
AU  - Palleis, Carla
AU  - Katzdobler, Sabrina
AU  - Rauchmann, Boris Stephan
AU  - Morbelli, Silvia
AU  - Chincarini, Andrea
AU  - Bruffaerts, Rose
AU  - Vandenberghe, Rik
AU  - Kramberger, Milica G
AU  - Trost, Maja
AU  - Garibotto, Valentina
AU  - Nicastro, Nicolas
AU  - Lathuilière, Aurélien
AU  - Lemstra, Afina W
AU  - van Berckel, Bart N M
AU  - Pilotto, Andrea
AU  - Padovani, Alessandro
AU  - Ochoa-Figueroa, Miguel A
AU  - Davidsson, Anette
AU  - Camacho, Valle
AU  - Peira, Enrico
AU  - Bauckneht, Matteo
AU  - Pardini, Matteo
AU  - Sambuceti, Gianmario
AU  - Aarsland, Dag
AU  - Nobili, Flavio
AU  - Gross, Mattes
AU  - Vöglein, Jonathan
AU  - Perneczky, Robert
AU  - Pogarell, Oliver
AU  - Buerger, Katharina
AU  - Franzmeier, Nikolai
AU  - Danek, Adrian
AU  - Levin, Johannes
AU  - Höglinger, Günter U
AU  - Bartenstein, Peter
AU  - Cumming, Paul
AU  - Rominger, Axel
AU  - Brendel, Matthias
TI  - Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission.
JO  - European journal of nuclear medicine and molecular imaging
VL  - 51
IS  - 4
SN  - 1619-7070
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DZNE-2024-00199
SP  - 1023 - 1034
PY  - 2024
AB  - Metabolic network analysis of FDG-PET utilizes an index of inter-regional correlation of resting state glucose metabolism and has been proven to provide complementary information regarding the disease process in parkinsonian syndromes. The goals of this study were (i) to evaluate pattern similarities of glucose metabolism and network connectivity in dementia with Lewy bodies (DLB) subjects with subthreshold dopaminergic loss compared to advanced disease stages and to (ii) investigate metabolic network alterations of FDG-PET for discrimination of patients with early DLB from other neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, multiple system atrophy) at individual patient level via principal component analysis (PCA).FDG-PETs of subjects with probable or possible DLB (n = 22) without significant dopamine deficiency (z-score < 2 in putamen binding loss on DaT-SPECT compared to healthy controls (HC)) were scaled by global-mean, prior to volume-of-interest-based analyses of relative glucose metabolism. Single region metabolic changes and network connectivity changes were compared against HC (n = 23) and against DLB subjects with significant dopamine deficiency (n = 86). PCA was applied to test discrimination of patients with DLB from disease controls (n = 101) at individual patient level.Similar patterns of hypo- (parietal- and occipital cortex) and hypermetabolism (basal ganglia, limbic system, motor cortices) were observed in DLB patients with and without significant dopamine deficiency when compared to HC. Metabolic connectivity alterations correlated between DLB patients with and without significant dopamine deficiency (R2 = 0.597, p < 0.01). A PCA trained by DLB patients with dopamine deficiency and HC discriminated DLB patients without significant dopaminergic loss from other neurodegenerative parkinsonian disorders at individual patient level (area-under-the-curve (AUC): 0.912).Disease-specific patterns of altered glucose metabolism and altered metabolic networks are present in DLB subjects without significant dopaminergic loss. Metabolic network alterations in FDG-PET can act as a supporting biomarker in the subgroup of DLB patients without significant dopaminergic loss at symptoms onset.
KW  - Humans
KW  - Lewy Body Disease: diagnostic imaging
KW  - Dopamine: metabolism
KW  - Fluorodeoxyglucose F18
KW  - Alzheimer Disease: metabolism
KW  - Positron-Emission Tomography
KW  - Glucose: metabolism
KW  - Metabolic Networks and Pathways
KW  - DaT-Scan (Other)
KW  - Dementia with Lewy bodies (Other)
KW  - FDG-PET (Other)
KW  - Metabolic connectivity (Other)
KW  - Dopamine (NLM Chemicals)
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
KW  - Glucose (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10881642
C6  - pmid:37971501
DO  - DOI:10.1007/s00259-023-06493-w
UR  - https://pub.dzne.de/record/268317
ER  -