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@ARTICLE{Stockbauer:268317,
      author       = {Stockbauer, Anna and Beyer, Leonie and Huber, Maria and
                      Kreuzer, Annika and Palleis, Carla and Katzdobler, Sabrina
                      and Rauchmann, Boris Stephan and Morbelli, Silvia and
                      Chincarini, Andrea and Bruffaerts, Rose and Vandenberghe,
                      Rik and Kramberger, Milica G and Trost, Maja and Garibotto,
                      Valentina and Nicastro, Nicolas and Lathuilière, Aurélien
                      and Lemstra, Afina W and van Berckel, Bart N M and Pilotto,
                      Andrea and Padovani, Alessandro and Ochoa-Figueroa, Miguel A
                      and Davidsson, Anette and Camacho, Valle and Peira, Enrico
                      and Bauckneht, Matteo and Pardini, Matteo and Sambuceti,
                      Gianmario and Aarsland, Dag and Nobili, Flavio and Gross,
                      Mattes and Vöglein, Jonathan and Perneczky, Robert and
                      Pogarell, Oliver and Buerger, Katharina and Franzmeier,
                      Nikolai and Danek, Adrian and Levin, Johannes and
                      Höglinger, Günter U and Bartenstein, Peter and Cumming,
                      Paul and Rominger, Axel and Brendel, Matthias},
      title        = {{M}etabolic network alterations as a supportive biomarker
                      in dementia with {L}ewy bodies with preserved dopamine
                      transmission.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {51},
      number       = {4},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DZNE-2024-00199},
      pages        = {1023 - 1034},
      year         = {2024},
      abstract     = {Metabolic network analysis of FDG-PET utilizes an index of
                      inter-regional correlation of resting state glucose
                      metabolism and has been proven to provide complementary
                      information regarding the disease process in parkinsonian
                      syndromes. The goals of this study were (i) to evaluate
                      pattern similarities of glucose metabolism and network
                      connectivity in dementia with Lewy bodies (DLB) subjects
                      with subthreshold dopaminergic loss compared to advanced
                      disease stages and to (ii) investigate metabolic network
                      alterations of FDG-PET for discrimination of patients with
                      early DLB from other neurodegenerative disorders
                      (Alzheimer's disease, Parkinson's disease, multiple system
                      atrophy) at individual patient level via principal component
                      analysis (PCA).FDG-PETs of subjects with probable or
                      possible DLB (n = 22) without significant dopamine
                      deficiency (z-score < 2 in putamen binding loss on DaT-SPECT
                      compared to healthy controls (HC)) were scaled by
                      global-mean, prior to volume-of-interest-based analyses of
                      relative glucose metabolism. Single region metabolic changes
                      and network connectivity changes were compared against HC (n
                      = 23) and against DLB subjects with significant dopamine
                      deficiency (n = 86). PCA was applied to test discrimination
                      of patients with DLB from disease controls (n = 101) at
                      individual patient level.Similar patterns of hypo-
                      (parietal- and occipital cortex) and hypermetabolism (basal
                      ganglia, limbic system, motor cortices) were observed in DLB
                      patients with and without significant dopamine deficiency
                      when compared to HC. Metabolic connectivity alterations
                      correlated between DLB patients with and without significant
                      dopamine deficiency (R2 = 0.597, p < 0.01). A PCA trained by
                      DLB patients with dopamine deficiency and HC discriminated
                      DLB patients without significant dopaminergic loss from
                      other neurodegenerative parkinsonian disorders at individual
                      patient level (area-under-the-curve (AUC):
                      0.912).Disease-specific patterns of altered glucose
                      metabolism and altered metabolic networks are present in DLB
                      subjects without significant dopaminergic loss. Metabolic
                      network alterations in FDG-PET can act as a supporting
                      biomarker in the subgroup of DLB patients without
                      significant dopaminergic loss at symptoms onset.},
      keywords     = {Humans / Lewy Body Disease: diagnostic imaging / Dopamine:
                      metabolism / Fluorodeoxyglucose F18 / Alzheimer Disease:
                      metabolism / Positron-Emission Tomography / Glucose:
                      metabolism / Metabolic Networks and Pathways / DaT-Scan
                      (Other) / Dementia with Lewy bodies (Other) / FDG-PET
                      (Other) / Metabolic connectivity (Other) / Dopamine (NLM
                      Chemicals) / Fluorodeoxyglucose F18 (NLM Chemicals) /
                      Glucose (NLM Chemicals)},
      cin          = {AG Haass / AG Simons / Clinical Research (Munich) / AG
                      Dichgans},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007 / I:(DE-2719)1110008 /
                      I:(DE-2719)1111015 / I:(DE-2719)5000022},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10881642},
      pubmed       = {pmid:37971501},
      doi          = {10.1007/s00259-023-06493-w},
      url          = {https://pub.dzne.de/record/268317},
}