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@ARTICLE{GordjiNejad:268479,
      author       = {Gordji-Nejad, Ali and Matusch, Andreas and Kleedörfer,
                      Sophie and Jayeshkumar Patel, Harshal and Drzezga, Alexander
                      and Elmenhorst, David and Binkofski, Ferdinand and Bauer,
                      Andreas},
      title        = {{S}ingle dose creatine improves cognitive performance and
                      induces changes in cerebral high energy phosphates during
                      sleep deprivation.},
      journal      = {Scientific reports},
      volume       = {14},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2024-00231},
      pages        = {4937},
      year         = {2024},
      abstract     = {The inverse effects of creatine supplementation and sleep
                      deprivation on high energy phosphates, neural creatine, and
                      cognitive performances suggest that creatine is a suitable
                      candidate for reducing the negative effects of sleep
                      deprivation. With this, the main obstacle is the limited
                      exogenous uptake by the central nervous system (CNS), making
                      creatine only effective over a long-term diet of weeks. Thus
                      far, only repeated dosing of creatine over weeks has been
                      studied, yielding detectable changes in CNS levels. Based on
                      the hypothesis that a high extracellular creatine
                      availability and increased intracellular energy consumption
                      will temporarily increase the central creatine uptake,
                      subjects were orally administered a high single dose of
                      creatinemonohydrate (0.35 g/kg) while performing cognitive
                      tests during sleep deprivation. Two consecutive 31P-MRS
                      scans, 1H-MRS, and cognitive tests were performed each at
                      evening baseline, 3, 5.5, and 7.5 h after single dose
                      creatine (0.35 g/kg) or placebo during sub-total 21 h sleep
                      deprivation (SD). Our results show that creatine induces
                      changes in PCr/Pi, ATP, tCr/tNAA, prevents a drop in pH
                      level, and improves cognitive performance and processing
                      speed. These outcomes suggest that a high single dose of
                      creatine can partially reverse metabolic alterations and
                      fatigue-related cognitive deterioration.},
      keywords     = {Humans / Creatine: pharmacology / Creatine: metabolism /
                      Sleep Deprivation: metabolism / Central Nervous System:
                      metabolism / Cognition: physiology / Phosphates:
                      pharmacology / Creatine (NLM Chemicals) / Phosphates (NLM
                      Chemicals)},
      cin          = {AG Boecker},
      ddc          = {600},
      cid          = {I:(DE-2719)1011202},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10902318},
      pubmed       = {pmid:38418482},
      doi          = {10.1038/s41598-024-54249-9},
      url          = {https://pub.dzne.de/record/268479},
}