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001     268479
005     20240403131604.0
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037 _ _ |a DZNE-2024-00231
041 _ _ |a English
082 _ _ |a 600
100 1 _ |a Gordji-Nejad, Ali
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245 _ _ |a Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.
260 _ _ |a [London]
|c 2024
|b Macmillan Publishers Limited, part of Springer Nature
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520 _ _ |a The inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation. With this, the main obstacle is the limited exogenous uptake by the central nervous system (CNS), making creatine only effective over a long-term diet of weeks. Thus far, only repeated dosing of creatine over weeks has been studied, yielding detectable changes in CNS levels. Based on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate (0.35 g/kg) while performing cognitive tests during sleep deprivation. Two consecutive 31P-MRS scans, 1H-MRS, and cognitive tests were performed each at evening baseline, 3, 5.5, and 7.5 h after single dose creatine (0.35 g/kg) or placebo during sub-total 21 h sleep deprivation (SD). Our results show that creatine induces changes in PCr/Pi, ATP, tCr/tNAA, prevents a drop in pH level, and improves cognitive performance and processing speed. These outcomes suggest that a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive deterioration.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Creatine: pharmacology
|2 MeSH
650 _ 2 |a Creatine: metabolism
|2 MeSH
650 _ 2 |a Sleep Deprivation: metabolism
|2 MeSH
650 _ 2 |a Central Nervous System: metabolism
|2 MeSH
650 _ 2 |a Cognition: physiology
|2 MeSH
650 _ 2 |a Phosphates: pharmacology
|2 MeSH
650 _ 7 |a Creatine
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650 _ 7 |a Phosphates
|2 NLM Chemicals
700 1 _ |a Matusch, Andreas
|b 1
700 1 _ |a Kleedörfer, Sophie
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700 1 _ |a Jayeshkumar Patel, Harshal
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700 1 _ |a Drzezga, Alexander
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700 1 _ |a Elmenhorst, David
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700 1 _ |a Binkofski, Ferdinand
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700 1 _ |a Bauer, Andreas
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773 _ _ |a 10.1038/s41598-024-54249-9
|g Vol. 14, no. 1, p. 4937
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|p 4937
|t Scientific reports
|v 14
|y 2024
|x 2045-2322
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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