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000268493 1001_ $$00000-0003-3538-6663$$aChang, Yinshui$$b0
000268493 245__ $$aTGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf.
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000268493 520__ $$aT follicular helper (TFH) cells are essential for effective antibody responses, but deciphering the intrinsic wiring of mouse TFH cells has long been hampered by the lack of a reliable protocol for their generation in vitro. We report that transforming growth factor-β (TGF-β) induces robust expression of TFH hallmark molecules CXCR5 and Bcl6 in activated mouse CD4+ T cells in vitro. TGF-β-induced mouse CXCR5+ TFH cells are phenotypically, transcriptionally, and functionally similar to in vivo-generated TFH cells and provide critical help to B cells. The study further reveals that TGF-β-induced CXCR5 expression is independent of Bcl6 but requires the transcription factor c-Maf. Classical TGF-β-containing T helper 17 (TH17)-inducing conditions also yield separate CXCR5+ and IL-17A-producing cells, highlighting shared and distinct cell fate trajectories of TFH and TH17 cells. We demonstrate that excess IL-2 in high-density T cell cultures interferes with the TGF-β-induced TFH cell program, that TFH and TH17 cells share a common developmental stage, and that c-Maf acts as a switch factor for TFH versus TH17 cell fates in TGF-β-rich environments in vitro and in vivo.
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000268493 650_7 $$2NLM Chemicals$$aTransforming Growth Factor beta
000268493 650_7 $$2NLM Chemicals$$aMaf protein, mouse
000268493 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins c-maf
000268493 650_2 $$2MeSH$$aAnimals
000268493 650_2 $$2MeSH$$aMice
000268493 650_2 $$2MeSH$$aT-Lymphocytes, Helper-Inducer
000268493 650_2 $$2MeSH$$aTransforming Growth Factor beta: metabolism
000268493 650_2 $$2MeSH$$aB-Lymphocytes
000268493 650_2 $$2MeSH$$aCD4-Positive T-Lymphocytes
000268493 650_2 $$2MeSH$$aCell Differentiation
000268493 650_2 $$2MeSH$$aProto-Oncogene Proteins c-maf: metabolism
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000268493 7001_ $$00000-0002-3476-6325$$aBach, Luisa$$b1
000268493 7001_ $$aHasiuk, Marko$$b2
000268493 7001_ $$aWen, Lifen$$b3
000268493 7001_ $$0P:(DE-2719)9000539$$aElmzzahi, Tarek$$b4$$udzne
000268493 7001_ $$00000-0003-0642-814X$$aTsui, Carlson$$b5
000268493 7001_ $$00000-0001-7482-3809$$aGutiérrez-Melo, Nicolás$$b6
000268493 7001_ $$00009-0009-3311-5051$$aSteffen, Teresa$$b7
000268493 7001_ $$aUtzschneider, Daniel T$$b8
000268493 7001_ $$00000-0002-5065-8092$$aRaj, Timsse$$b9
000268493 7001_ $$00000-0001-7613-6244$$aJost, Paul Jonas$$b10
000268493 7001_ $$00000-0002-3276-6313$$aHeink, Sylvia$$b11
000268493 7001_ $$aCheng, Jingyuan$$b12
000268493 7001_ $$00000-0003-3884-7373$$aBurton, Oliver T$$b13
000268493 7001_ $$00000-0002-9738-6805$$aZeiträg, Julia$$b14
000268493 7001_ $$00000-0001-8164-3734$$aAlterauge, Dominik$$b15
000268493 7001_ $$00000-0003-2495-3079$$aDahlström, Frank$$b16
000268493 7001_ $$00000-0002-8204-9750$$aBecker, Jennifer-Christin$$b17
000268493 7001_ $$aKastl, Melanie$$b18
000268493 7001_ $$aSymeonidis, Konstantinos$$b19
000268493 7001_ $$0P:(DE-2719)9002579$$avan Uelft, Martina$$b20$$udzne
000268493 7001_ $$0P:(DE-2719)2812750$$aBecker, Matthias Kai Holger$$b21$$udzne
000268493 7001_ $$00000-0002-8880-0808$$aReschke, Sarah$$b22
000268493 7001_ $$00000-0001-5112-9507$$aKrebs, Stefan$$b23
000268493 7001_ $$00000-0002-3994-2332$$aBlum, Helmut$$b24
000268493 7001_ $$00000-0002-4522-6332$$aAbdullah, Zeinab$$b25
000268493 7001_ $$aPaeschke, Katrin$$b26
000268493 7001_ $$00000-0002-6887-8819$$aOhnmacht, Caspar$$b27
000268493 7001_ $$00000-0003-2202-1876$$aNeumann, Christian$$b28
000268493 7001_ $$00000-0002-6272-4085$$aListon, Adrian$$b29
000268493 7001_ $$00000-0003-1000-7989$$aMeissner, Felix$$b30
000268493 7001_ $$00000-0002-3633-0955$$aKorn, Thomas$$b31
000268493 7001_ $$aHasenauer, Jan$$b32
000268493 7001_ $$00000-0002-2263-8545$$aHeissmeyer, Vigo$$b33
000268493 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc-Daniel$$b34$$udzne
000268493 7001_ $$00000-0002-6312-6968$$aKallies, Axel$$b35
000268493 7001_ $$00000-0002-3359-8796$$aJeker, Lukas T$$b36
000268493 7001_ $$00000-0001-8385-8288$$aBaumjohann, Dirk$$b37
000268493 773__ $$0PERI:(DE-600)2862556-0$$a10.1126/sciimmunol.add4818$$gVol. 9, no. 93, p. eadd4818$$n93$$peadd4818$$tScience immunology$$v9$$x2470-9468$$y2024
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