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000268495 1001_ $$aTorres, Santiago Valle$$b0
000268495 245__ $$aTwo regulatory T cell populations in the visceral adipose tissue shape systemic metabolism.
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000268495 520__ $$aVisceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis and glucose tolerance. Here, we show that the VAT harbors two distinct Treg cell populations: prototypical serum stimulation 2-positive (ST2+) Treg cells that are enriched in males and a previously uncharacterized population of C-X-C motif chemokine receptor 3-positive (CXCR3+) Treg cells that are enriched in females. We show that the transcription factors GATA-binding protein 3 and peroxisome proliferator-activated receptor-γ, together with the cytokine interleukin-33, promote the differentiation of ST2+ VAT Treg cells but repress CXCR3+ Treg cells. Conversely, the differentiation of CXCR3+ Treg cells is mediated by the cytokine interferon-γ and the transcription factor T-bet, which also antagonize ST2+ Treg cells. Finally, we demonstrate that ST2+ Treg cells preserve glucose homeostasis, whereas CXCR3+ Treg cells restrain inflammation in lean VAT and prevent glucose intolerance under high-fat diet conditions. Overall, this study defines two molecularly and developmentally distinct VAT Treg cell types with unique context- and sex-specific functions.
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000268495 650_7 $$2NLM Chemicals$$aInterleukin-1 Receptor-Like 1 Protein
000268495 650_7 $$2NLM Chemicals$$aCytokines
000268495 650_7 $$0IY9XDZ35W2$$2NLM Chemicals$$aGlucose
000268495 650_2 $$2MeSH$$aFemale
000268495 650_2 $$2MeSH$$aMale
000268495 650_2 $$2MeSH$$aHumans
000268495 650_2 $$2MeSH$$aT-Lymphocytes, Regulatory
000268495 650_2 $$2MeSH$$aInterleukin-1 Receptor-Like 1 Protein
000268495 650_2 $$2MeSH$$aIntra-Abdominal Fat
000268495 650_2 $$2MeSH$$aCytokines
000268495 650_2 $$2MeSH$$aInflammation
000268495 650_2 $$2MeSH$$aGlucose
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000268495 7001_ $$00000-0002-6585-9532$$aMan, Kevin$$b1
000268495 7001_ $$0P:(DE-2719)9000539$$aElmzzahi, Tarek$$b2$$udzne
000268495 7001_ $$0P:(DE-2719)2814800$$aMalko, Darya$$b3$$udzne
000268495 7001_ $$00000-0002-0421-3957$$aChisanga, David$$b4
000268495 7001_ $$00000-0002-9746-2839$$aLiao, Yang$$b5
000268495 7001_ $$00009-0006-3786-4680$$aProut, Melanie$$b6
000268495 7001_ $$00000-0002-1024-1524$$aAbbott, Caitlin A$$b7
000268495 7001_ $$aTang, Adelynn$$b8
000268495 7001_ $$0P:(DE-HGF)0$$aWu, Jian$$b9
000268495 7001_ $$0P:(DE-2719)2812750$$aBecker, Matthias Kai Holger$$b10$$udzne
000268495 7001_ $$aMason, Teisha$$b11
000268495 7001_ $$aHaynes, Vanessa$$b12
000268495 7001_ $$00000-0003-0642-814X$$aTsui, Carlson$$b13
000268495 7001_ $$0P:(DE-2719)2814240$$aHadaddzadeh Shakiba, Mehrnoush$$b14$$udzne
000268495 7001_ $$0P:(DE-2719)9000568$$aHamada, Doaa$$b15$$udzne
000268495 7001_ $$aBritt, Kara$$b16
000268495 7001_ $$00000-0001-5251-7835$$aGroom, Joanna R$$b17
000268495 7001_ $$aMcColl, Shaun R$$b18
000268495 7001_ $$aShi, Wei$$b19
000268495 7001_ $$00000-0003-4064-4188$$aWatt, Matthew J$$b20
000268495 7001_ $$00000-0002-5721-0442$$aLe Gros, Graham$$b21
000268495 7001_ $$00000-0002-3684-4331$$aPal, Bhupinder$$b22
000268495 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc-Daniel$$b23$$udzne
000268495 7001_ $$00000-0002-1620-7781$$aVasanthakumar, Ajithkumar$$b24
000268495 7001_ $$00000-0002-6312-6968$$aKallies, Axel$$b25
000268495 773__ $$0PERI:(DE-600)2026412-4$$a10.1038/s41590-024-01753-9$$gVol. 25, no. 3, p. 496 - 511$$n3$$p496 - 511$$tNature immunology$$v25$$x1529-2908$$y2024
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