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@ARTICLE{Torres:268495,
      author       = {Torres, Santiago Valle and Man, Kevin and Elmzzahi, Tarek
                      and Malko, Darya and Chisanga, David and Liao, Yang and
                      Prout, Melanie and Abbott, Caitlin A and Tang, Adelynn and
                      Wu, Jian and Becker, Matthias Kai Holger and Mason, Teisha
                      and Haynes, Vanessa and Tsui, Carlson and Hadaddzadeh
                      Shakiba, Mehrnoush and Hamada, Doaa and Britt, Kara and
                      Groom, Joanna R and McColl, Shaun R and Shi, Wei and Watt,
                      Matthew J and Le Gros, Graham and Pal, Bhupinder and Beyer,
                      Marc-Daniel and Vasanthakumar, Ajithkumar and Kallies, Axel},
      title        = {{T}wo regulatory {T} cell populations in the visceral
                      adipose tissue shape systemic metabolism.},
      journal      = {Nature immunology},
      volume       = {25},
      number       = {3},
      issn         = {1529-2908},
      address      = {London},
      publisher    = {Springer Nature Limited},
      reportid     = {DZNE-2024-00241},
      pages        = {496 - 511},
      year         = {2024},
      abstract     = {Visceral adipose tissue (VAT) is an energy store and
                      endocrine organ critical for metabolic homeostasis.
                      Regulatory T (Treg) cells restrain inflammation to preserve
                      VAT homeostasis and glucose tolerance. Here, we show that
                      the VAT harbors two distinct Treg cell populations:
                      prototypical serum stimulation 2-positive (ST2+) Treg cells
                      that are enriched in males and a previously uncharacterized
                      population of C-X-C motif chemokine receptor 3-positive
                      (CXCR3+) Treg cells that are enriched in females. We show
                      that the transcription factors GATA-binding protein 3 and
                      peroxisome proliferator-activated receptor-γ, together with
                      the cytokine interleukin-33, promote the differentiation of
                      ST2+ VAT Treg cells but repress CXCR3+ Treg cells.
                      Conversely, the differentiation of CXCR3+ Treg cells is
                      mediated by the cytokine interferon-γ and the transcription
                      factor T-bet, which also antagonize ST2+ Treg cells.
                      Finally, we demonstrate that ST2+ Treg cells preserve
                      glucose homeostasis, whereas CXCR3+ Treg cells restrain
                      inflammation in lean VAT and prevent glucose intolerance
                      under high-fat diet conditions. Overall, this study defines
                      two molecularly and developmentally distinct VAT Treg cell
                      types with unique context- and sex-specific functions.},
      keywords     = {Female / Male / Humans / T-Lymphocytes, Regulatory /
                      Interleukin-1 Receptor-Like 1 Protein / Intra-Abdominal Fat
                      / Cytokines / Inflammation / Glucose / Interleukin-1
                      Receptor-Like 1 Protein (NLM Chemicals) / Cytokines (NLM
                      Chemicals) / Glucose (NLM Chemicals)},
      cin          = {AG Beyer / AG Becker / PRECISE},
      ddc          = {610},
      cid          = {I:(DE-2719)1013035 / I:(DE-2719)5000079 /
                      I:(DE-2719)1013031},
      pnm          = {351 - Brain Function (POF4-351) / 354 - Disease Prevention
                      and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-354},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38356058},
      doi          = {10.1038/s41590-024-01753-9},
      url          = {https://pub.dzne.de/record/268495},
}