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@ARTICLE{Toda:268496,
      author       = {Toda, Tomohisa and Bedrosian, Tracy A and Schafer, Simon T
                      and Cuoco, Michael S and Linker, Sara B and Ghassemzadeh,
                      Saeed and Mitchell, Lisa and Whiteley, Jack T and Novaresi,
                      Nicole and McDonald, Aidan H and Gallina, Iryna S and Yoon,
                      Hyojung and Hester, Mark E and Pena, Monique and Lim,
                      Christina and Suljic, Emelia and AlFatah Mansour, Abed and
                      Boulard, Matthieu and Parylak, Sarah L and Gage, Fred H},
      title        = {{L}ong interspersed nuclear elements safeguard neural
                      progenitors from precocious differentiation.},
      journal      = {Cell reports},
      volume       = {43},
      number       = {2},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2024-00242},
      pages        = {113774},
      year         = {2024},
      abstract     = {Long interspersed nuclear element-1 (L1 or LINE-1) is a
                      highly abundant mobile genetic element in both humans and
                      mice, comprising almost $20\%$ of each genome. L1s are
                      silenced by several mechanisms, as their uncontrolled
                      expression has the potential to induce genomic instability.
                      However, L1s are paradoxically expressed at high levels in
                      differentiating neural progenitor cells. Using in vitro and
                      in vivo techniques to modulate L1 expression, we report that
                      L1s play a critical role in both human and mouse brain
                      development by regulating the rate of neural differentiation
                      in a reverse-transcription-independent manner.},
      keywords     = {Humans / Animals / Mice / Cell Differentiation / Genomic
                      Instability / Long Interspersed Nucleotide Elements / Neural
                      Stem Cells / CP: Developmental biology (Other) / CP:
                      Neuroscience (Other) / L1 (Other) / LINE-1 (Other) / brain
                      development (Other) / neural progenitor cells (Other) /
                      repetitive elements (Other)},
      cin          = {AG Toda},
      ddc          = {610},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10948021},
      pubmed       = {pmid:38349791},
      doi          = {10.1016/j.celrep.2024.113774},
      url          = {https://pub.dzne.de/record/268496},
}