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001     268496
005     20240403113252.0
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024 7 _ |a 10.1016/j.celrep.2024.113774
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037 _ _ |a DZNE-2024-00242
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082 _ _ |a 610
100 1 _ |a Toda, Tomohisa
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245 _ _ |a Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation.
260 _ _ |a [New York, NY]
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520 _ _ |a Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.
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650 _ 7 |a CP: Developmental biology
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650 _ 7 |a CP: Neuroscience
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650 _ 7 |a L1
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650 _ 7 |a LINE-1
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650 _ 7 |a brain development
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650 _ 7 |a neural progenitor cells
|2 Other
650 _ 7 |a repetitive elements
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Genomic Instability
|2 MeSH
650 _ 2 |a Long Interspersed Nucleotide Elements
|2 MeSH
650 _ 2 |a Neural Stem Cells
|2 MeSH
700 1 _ |a Bedrosian, Tracy A
|b 1
700 1 _ |a Schafer, Simon T
|b 2
700 1 _ |a Cuoco, Michael S
|b 3
700 1 _ |a Linker, Sara B
|b 4
700 1 _ |a Ghassemzadeh, Saeed
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700 1 _ |a Mitchell, Lisa
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700 1 _ |a Whiteley, Jack T
|b 7
700 1 _ |a Novaresi, Nicole
|b 8
700 1 _ |a McDonald, Aidan H
|b 9
700 1 _ |a Gallina, Iryna S
|b 10
700 1 _ |a Yoon, Hyojung
|b 11
700 1 _ |a Hester, Mark E
|b 12
700 1 _ |a Pena, Monique
|b 13
700 1 _ |a Lim, Christina
|b 14
700 1 _ |a Suljic, Emelia
|b 15
700 1 _ |a AlFatah Mansour, Abed
|b 16
700 1 _ |a Boulard, Matthieu
|b 17
700 1 _ |a Parylak, Sarah L
|b 18
700 1 _ |a Gage, Fred H
|b 19
773 _ _ |a 10.1016/j.celrep.2024.113774
|g Vol. 43, no. 2, p. 113774 -
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856 4 _ |u https://pub.dzne.de/record/268496/files/DZNE-2024-00242%20SUP.zip
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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