%0 Journal Article
%A Arlt, Friederike A
%A Miske, Ramona
%A Machule, Marie-Luise
%A Broegger Christensen, Peter
%A Mindorf, Swantje
%A Teegen, Bianca
%A Borowski, Kathrin
%A Buthut, Maria
%A Rößling, Rosa
%A Sánchez-Sendín, Elisa
%A van Hoof, Scott
%A Cordero-Gómez, César
%A Bünger, Isabel
%A Radbruch, Helena
%A Kraft, Andrea
%A Ayzenberg, Ilya
%A Klausewitz, Jaqueline
%A Hansen, Niels
%A Timäus, Charles
%A Körtvelyessy, Peter
%A Postert, Thomas
%A Baur-Seack, Kirsten
%A Rost, Constanze
%A Brunkhorst, Robert
%A Doppler, Kathrin
%A Haigis, Niklas
%A Hamann, Gerhard
%A Kunze, Albrecht
%A Stützer, Alexandra
%A Maschke, Matthias
%A Melzer, Nico
%A Rosenow, Felix
%A Siebenbrodt, Kai
%A Stenør, Christian
%A Dichgans, Martin
%A Georgakis, Marios K
%A Fang, Rong
%A Petzold, Gabor C
%A Görtler, Michael
%A Zerr, Inga
%A Wunderlich, Silke
%A Mihaljevic, Ivan
%A Turko, Paul
%A Schmidt Ettrup, Marianne
%A Buchholz, Emilie
%A Foverskov Rasmussen, Helle
%A Nasouti, Mahoor
%A Talucci, Ivan
%A Maric, Hans M
%A Heinemann, Stefan H
%A Endres, Matthias
%A Komorowski, Lars
%A Prüss, Harald
%T KCNA2 IgG autoimmunity in neuropsychiatric diseases.
%J Brain, behavior and immunity
%V 117
%@ 0889-1591
%C Orlando, Fla.
%I Academic Press
%M DZNE-2024-00244
%P 399 - 411
%D 2024
%X Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice.We retrospectively collected comprehensive clinical and paraclinical data of 35 patients with KCNA2 IgG autoantibodies detected in cell-based and tissue-based assays. Patients' sera and cerebrospinal fluid (CSF) were used for characterization of the antigen, clinical-serological correlations, and determination of IgG subclasses.KCNA2 autoantibody-positive patients (n = 35, median age at disease onset of 65 years, range of 16-83 years, 74 
%K Animals
%K Humans
%K Male
%K Adolescent
%K Young Adult
%K Adult
%K Middle Aged
%K Aged
%K Aged, 80 and over
%K Female
%K Autoimmunity
%K Retrospective Studies
%K Autoantibodies
%K Seizures
%K Autoimmune Diseases of the Nervous System
%K Mammals
%K Kv1.2 Potassium Channel
%K Encephalitis
%K Hashimoto Disease
%K Autoantibody (Other)
%K Autoimmune dementia (Other)
%K Autoimmune encephalitis (Other)
%K Epilepsy (Other)
%K Immunotherapy (Other)
%K KCNA2 (Other)
%K Kv1.2 (Other)
%K Autoantibodies (NLM Chemicals)
%K KCNA2 protein, human (NLM Chemicals)
%K Kv1.2 Potassium Channel (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38309639
%R 10.1016/j.bbi.2024.01.220
%U https://pub.dzne.de/record/268498