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000268719 037__ $$aDZNE-2024-00298
000268719 041__ $$aEnglish
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000268719 1001_ $$0P:(DE-2719)9001452$$avon Rennenberg, Regina$$b0$$eFirst author
000268719 245__ $$aHigh-Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke-Results of the DEMDAS Study.
000268719 260__ $$aNew York, NY$$bAssociation$$c2024
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000268719 520__ $$aSubclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown.We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study. Patients underwent neuropsychological testing 6 and 12 months after the index event. Test results were classified into 5 cognitive domains (language, memory, executive function, attention, and visuospatial function). SVD markers (lacunes, cerebral microbleeds, white matter hyperintensities, and enlarged perivascular spaces) were assessed on cranial magnetic resonance imaging to constitute a global SVD score. We examined the association between hs-cTnT (hs-cTn T levels) and cognitive domains as well as the global SVD score and individual SVD markers, respectively. Measurement of cognitive and SVD-marker analyses were performed in 385 and 466 patients with available hs-cTnT levels, respectively. In analyses adjusted for demographic characteristics, cardiovascular risk factors, and cognitive status at baseline, higher hs-cTnT was negatively associated with the cognitive domains 'attention' up to 12 months of follow-up (beta-coefficient, -0.273 [95% CI, -0.436 to -0.109]) and 'executive function' after 12 months. Higher hs-cTnT was associated with the global SVD score (adjusted odds ratio, 1.95 [95% CI, 1.27-3.00]) and the white matter hyperintensities and lacune subscores.In patients with stroke, hs-cTnT is associated with a higher burden of SVD markers and cognitive function in domains linked to vascular cognitive impairment.URL: https://www.clinicaltrials.gov; Unique identifier: NCT01334749.
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000268719 650_7 $$2Other$$aacute stroke
000268719 650_7 $$2Other$$acardiac troponin
000268719 650_7 $$2Other$$acognitive impairment
000268719 650_7 $$2Other$$aheart and brain axis
000268719 650_7 $$2NLM Chemicals$$aTroponin T
000268719 650_2 $$2MeSH$$aHumans
000268719 650_2 $$2MeSH$$aTroponin T
000268719 650_2 $$2MeSH$$aProspective Studies
000268719 650_2 $$2MeSH$$aNeurodegenerative Diseases: complications
000268719 650_2 $$2MeSH$$aStroke: diagnosis
000268719 650_2 $$2MeSH$$aStroke: epidemiology
000268719 650_2 $$2MeSH$$aStroke: complications
000268719 650_2 $$2MeSH$$aCognition
000268719 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000268719 650_2 $$2MeSH$$aCognitive Dysfunction: epidemiology
000268719 650_2 $$2MeSH$$aCognitive Dysfunction: etiology
000268719 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: epidemiology
000268719 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: complications
000268719 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000268719 650_2 $$2MeSH$$aDementia
000268719 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian$$b1
000268719 7001_ $$0P:(DE-2719)9000189$$aLiman, Thomas G$$b2
000268719 7001_ $$00000-0002-6925-4768$$aHellwig, Simon$$b3
000268719 7001_ $$00000-0002-2478-3500$$aRiegler, Christoph$$b4
000268719 7001_ $$0P:(DE-2719)9001514$$aScheitz, Jan F$$b5
000268719 7001_ $$0P:(DE-HGF)0$$aGeorgakis, Marios K$$b6
000268719 7001_ $$0P:(DE-HGF)0$$aFang, Rong$$b7
000268719 7001_ $$0P:(DE-2719)2811949$$aBode, Felix$$b8$$udzne
000268719 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b9$$udzne
000268719 7001_ $$0P:(DE-2719)2812183$$aHermann, Peter$$b10
000268719 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b11
000268719 7001_ $$0P:(DE-2719)2811292$$aGörtler, Michael$$b12
000268719 7001_ $$aBernkopf, Kathleen$$b13
000268719 7001_ $$aWunderlich, Silke$$b14
000268719 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b15
000268719 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b16$$eLast author
000268719 7001_ $$a, DEMDAS investigators$$b17$$eCollaboration Author
000268719 7001_ $$aEndres, Matthias$$b18$$eContributor
000268719 7001_ $$aLiman, Thomas G$$b19$$eContributor
000268719 7001_ $$aKerti, Lucia$$b20$$eContributor
000268719 7001_ $$aNolte, Christian H$$b21$$eContributor
000268719 7001_ $$aWittenberg, Tatjana$$b22$$eContributor
000268719 7001_ $$aScheitz, Jan F$$b23$$eContributor
000268719 7001_ $$aPrüß, Harald$$b24$$eContributor
000268719 7001_ $$aSperber, Pia Sophie$$b25$$eContributor
000268719 7001_ $$aNave, Alexander H$$b26$$eContributor
000268719 7001_ $$aIbaroule, Anna Kufner$$b27$$eContributor
000268719 7001_ $$aPetzold, Gabor$$b28$$eContributor
000268719 7001_ $$aBode, Felix$$b29$$eContributor
000268719 7001_ $$aStösser, Sebastian$$b30$$eContributor
000268719 7001_ $$aMeissner, Julius$$b31$$eContributor
000268719 7001_ $$aEbrahimi, Taraneh$$b32$$eContributor
000268719 7001_ $$aNordsiek, Julia$$b33$$eContributor
000268719 7001_ $$aBeckonert, Niklas$$b34$$eContributor
000268719 7001_ $$aKindler, Christine$$b35$$eContributor
000268719 7001_ $$aZerr, Inga$$b36$$eContributor
000268719 7001_ $$aHermann, Peter$$b37$$eContributor
000268719 7001_ $$aSchmitz, Matthias$$b38$$eContributor
000268719 7001_ $$aGoebel, Stefan$$b39$$eContributor
000268719 7001_ $$aBunck, Timothy$$b40$$eContributor
000268719 7001_ $$aSchütte-Schmidt, Julia$$b41$$eContributor
000268719 7001_ $$aNuhn, Sabine$$b42$$eContributor
000268719 7001_ $$aVolpers, Corinna$$b43$$eContributor
000268719 7001_ $$aDechent, Peter$$b44$$eContributor
000268719 7001_ $$aBähr, Mathias$$b45$$eContributor
000268719 7001_ $$aGörtler, Michael$$b46$$eContributor
000268719 7001_ $$aGlanz, Wenzel$$b47$$eContributor
000268719 7001_ $$aPerosa, Valentina$$b48$$eContributor
000268719 7001_ $$aDichgans, Martin$$b49$$eContributor
000268719 7001_ $$aWollenweber, Frank$$b50$$eContributor
000268719 7001_ $$aFang, Rong$$b51$$eContributor
000268719 7001_ $$aJanowitz, Daniel$$b52$$eContributor
000268719 7001_ $$aWaegemann, Karin$$b53$$eContributor
000268719 7001_ $$aTiedt, Steffen$$b54$$eContributor
000268719 7001_ $$aWunderlich, Silke$$b55$$eContributor
000268719 7001_ $$aIkenberg, Benno$$b56$$eContributor
000268719 7001_ $$aBernkopf, Kathleen$$b57$$eContributor
000268719 7001_ $$aHuber, Christiane$$b58$$eContributor
000268719 7001_ $$aPoppert, Holger$$b59$$eContributor
000268719 7001_ $$aDüring, Marco$$b60$$eContributor
000268719 7001_ $$aAraque Caballero, Miguel Ángel$$b61$$eContributor
000268719 7001_ $$aGieserich, Benno$$b62$$eContributor
000268719 7001_ $$aDewenter, Anna$$b63$$eContributor
000268719 7001_ $$aDobisch, Laura$$b64$$eContributor
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000268719 7001_ $$aSpottke, Annika$$b67$$eContributor
000268719 7001_ $$aStöcker, Tony$$b68$$eContributor
000268719 7001_ $$aBartenstein, Peter$$b69$$eContributor
000268719 7001_ $$aWagner, Michael$$b70$$eContributor
000268719 773__ $$0PERI:(DE-600)2653953-6$$a10.1161/JAHA.123.033439$$gVol. 13, no. 6, p. e033439$$n6$$pe033439$$tJournal of the American Heart Association$$v13$$x2047-9980$$y2024
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