TY  - JOUR
AU  - von Rennenberg, Regina
AU  - Nolte, Christian
AU  - Liman, Thomas G
AU  - Hellwig, Simon
AU  - Riegler, Christoph
AU  - Scheitz, Jan F
AU  - Georgakis, Marios K
AU  - Fang, Rong
AU  - Bode, Felix
AU  - Petzold, Gabor C
AU  - Hermann, Peter
AU  - Zerr, Inga
AU  - Görtler, Michael
AU  - Bernkopf, Kathleen
AU  - Wunderlich, Silke
AU  - Dichgans, Martin
AU  - Endres, Matthias
TI  - High-Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke-Results of the DEMDAS Study.
JO  - Journal of the American Heart Association
VL  - 13
IS  - 6
SN  - 2047-9980
CY  - New York, NY
PB  - Association
M1  - DZNE-2024-00298
SP  - e033439
PY  - 2024
AB  - Subclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown.We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study. Patients underwent neuropsychological testing 6 and 12 months after the index event. Test results were classified into 5 cognitive domains (language, memory, executive function, attention, and visuospatial function). SVD markers (lacunes, cerebral microbleeds, white matter hyperintensities, and enlarged perivascular spaces) were assessed on cranial magnetic resonance imaging to constitute a global SVD score. We examined the association between hs-cTnT (hs-cTn T levels) and cognitive domains as well as the global SVD score and individual SVD markers, respectively. Measurement of cognitive and SVD-marker analyses were performed in 385 and 466 patients with available hs-cTnT levels, respectively. In analyses adjusted for demographic characteristics, cardiovascular risk factors, and cognitive status at baseline, higher hs-cTnT was negatively associated with the cognitive domains 'attention' up to 12 months of follow-up (beta-coefficient, -0.273 [95
KW  - Humans
KW  - Troponin T
KW  - Prospective Studies
KW  - Neurodegenerative Diseases: complications
KW  - Stroke: diagnosis
KW  - Stroke: epidemiology
KW  - Stroke: complications
KW  - Cognition
KW  - Cognitive Dysfunction: diagnosis
KW  - Cognitive Dysfunction: epidemiology
KW  - Cognitive Dysfunction: etiology
KW  - Cerebral Small Vessel Diseases: epidemiology
KW  - Cerebral Small Vessel Diseases: complications
KW  - Magnetic Resonance Imaging
KW  - Dementia
KW  - acute stroke (Other)
KW  - cardiac troponin (Other)
KW  - cognitive impairment (Other)
KW  - heart and brain axis (Other)
KW  - Troponin T (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11010029
C6  - pmid:38456438
DO  - DOI:10.1161/JAHA.123.033439
UR  - https://pub.dzne.de/record/268719
ER  -