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@ARTICLE{vonRennenberg:268719,
      author       = {von Rennenberg, Regina and Nolte, Christian and Liman,
                      Thomas G and Hellwig, Simon and Riegler, Christoph and
                      Scheitz, Jan F and Georgakis, Marios K and Fang, Rong and
                      Bode, Felix and Petzold, Gabor C and Hermann, Peter and
                      Zerr, Inga and Görtler, Michael and Bernkopf, Kathleen and
                      Wunderlich, Silke and Dichgans, Martin and Endres, Matthias},
      collaboration = {, DEMDAS investigators},
      othercontributors = {Endres, Matthias and Liman, Thomas G and Kerti, Lucia and
                          Nolte, Christian H and Wittenberg, Tatjana and Scheitz, Jan
                          F and Prüß, Harald and Sperber, Pia Sophie and Nave,
                          Alexander H and Ibaroule, Anna Kufner and Petzold, Gabor and
                          Bode, Felix and Stösser, Sebastian and Meissner, Julius and
                          Ebrahimi, Taraneh and Nordsiek, Julia and Beckonert, Niklas
                          and Kindler, Christine and Zerr, Inga and Hermann, Peter and
                          Schmitz, Matthias and Goebel, Stefan and Bunck, Timothy and
                          Schütte-Schmidt, Julia and Nuhn, Sabine and Volpers,
                          Corinna and Dechent, Peter and Bähr, Mathias and Görtler,
                          Michael and Glanz, Wenzel and Perosa, Valentina and
                          Dichgans, Martin and Wollenweber, Frank and Fang, Rong and
                          Janowitz, Daniel and Waegemann, Karin and Tiedt, Steffen and
                          Wunderlich, Silke and Ikenberg, Benno and Bernkopf, Kathleen
                          and Huber, Christiane and Poppert, Holger and Düring, Marco
                          and Araque Caballero, Miguel Ángel and Gieserich, Benno and
                          Dewenter, Anna and Dobisch, Laura and Neumann, Katja and
                          Speck, Oliver and Spottke, Annika and Stöcker, Tony and
                          Bartenstein, Peter and Wagner, Michael},
      title        = {{H}igh-{S}ensitivity {C}ardiac {T}roponin {T} and
                      {C}ognitive {F}unction {O}ver 12 {M}onths {A}fter
                      {S}troke-{R}esults of the {DEMDAS} {S}tudy.},
      journal      = {Journal of the American Heart Association},
      volume       = {13},
      number       = {6},
      issn         = {2047-9980},
      address      = {New York, NY},
      publisher    = {Association},
      reportid     = {DZNE-2024-00298},
      pages        = {e033439},
      year         = {2024},
      abstract     = {Subclinical myocardial injury in form of hs-cTn
                      (high-sensitivity cardiac troponin) levels has been
                      associated with cognitive impairment and imaging markers of
                      cerebral small vessel disease (SVD) in population-based and
                      cardiovascular cohorts. Whether hs-cTn is associated with
                      domain-specific cognitive decline and SVD burden in patients
                      with stroke remains unknown.We analyzed patients with acute
                      stroke without premorbid dementia from the prospective
                      multicenter DEMDAS (DZNE [German Center for
                      Neurodegenerative Disease]-Mechanisms of Dementia after
                      Stroke) study. Patients underwent neuropsychological testing
                      6 and 12 months after the index event. Test results were
                      classified into 5 cognitive domains (language, memory,
                      executive function, attention, and visuospatial function).
                      SVD markers (lacunes, cerebral microbleeds, white matter
                      hyperintensities, and enlarged perivascular spaces) were
                      assessed on cranial magnetic resonance imaging to constitute
                      a global SVD score. We examined the association between
                      hs-cTnT (hs-cTn T levels) and cognitive domains as well as
                      the global SVD score and individual SVD markers,
                      respectively. Measurement of cognitive and SVD-marker
                      analyses were performed in 385 and 466 patients with
                      available hs-cTnT levels, respectively. In analyses adjusted
                      for demographic characteristics, cardiovascular risk
                      factors, and cognitive status at baseline, higher hs-cTnT
                      was negatively associated with the cognitive domains
                      'attention' up to 12 months of follow-up (beta-coefficient,
                      -0.273 $[95\%$ CI, -0.436 to -0.109]) and 'executive
                      function' after 12 months. Higher hs-cTnT was associated
                      with the global SVD score (adjusted odds ratio, 1.95 $[95\%$
                      CI, 1.27-3.00]) and the white matter hyperintensities and
                      lacune subscores.In patients with stroke, hs-cTnT is
                      associated with a higher burden of SVD markers and cognitive
                      function in domains linked to vascular cognitive
                      impairment.URL: https://www.clinicaltrials.gov; Unique
                      identifier: NCT01334749.},
      keywords     = {Humans / Troponin T / Prospective Studies /
                      Neurodegenerative Diseases: complications / Stroke:
                      diagnosis / Stroke: epidemiology / Stroke: complications /
                      Cognition / Cognitive Dysfunction: diagnosis / Cognitive
                      Dysfunction: epidemiology / Cognitive Dysfunction: etiology
                      / Cerebral Small Vessel Diseases: epidemiology / Cerebral
                      Small Vessel Diseases: complications / Magnetic Resonance
                      Imaging / Dementia / acute stroke (Other) / cardiac troponin
                      (Other) / cognitive impairment (Other) / heart and brain
                      axis (Other) / Troponin T (NLM Chemicals)},
      cin          = {AG Endres / AG Dichgans / AG Petzold ; AG Petzold / AG
                      Zerr},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005 / I:(DE-2719)5000022 /
                      I:(DE-2719)1013020 / I:(DE-2719)1440011-1},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11010029},
      pubmed       = {pmid:38456438},
      doi          = {10.1161/JAHA.123.033439},
      url          = {https://pub.dzne.de/record/268719},
}