Home > Publications Database > High-Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke-Results of the DEMDAS Study. > print

001     268719
005     20240808164551.0
024 7 _ |a pmc:PMC11010029
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024 7 _ |a 10.1161/JAHA.123.033439
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024 7 _ |a pmid:38456438
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024 7 _ |a altmetric:161078992
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037 _ _ |a DZNE-2024-00298
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a von Rennenberg, Regina
|0 P:(DE-2719)9001452
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245 _ _ |a High-Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke-Results of the DEMDAS Study.
260 _ _ |a New York, NY
|c 2024
|b Association
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Subclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown.We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study. Patients underwent neuropsychological testing 6 and 12 months after the index event. Test results were classified into 5 cognitive domains (language, memory, executive function, attention, and visuospatial function). SVD markers (lacunes, cerebral microbleeds, white matter hyperintensities, and enlarged perivascular spaces) were assessed on cranial magnetic resonance imaging to constitute a global SVD score. We examined the association between hs-cTnT (hs-cTn T levels) and cognitive domains as well as the global SVD score and individual SVD markers, respectively. Measurement of cognitive and SVD-marker analyses were performed in 385 and 466 patients with available hs-cTnT levels, respectively. In analyses adjusted for demographic characteristics, cardiovascular risk factors, and cognitive status at baseline, higher hs-cTnT was negatively associated with the cognitive domains 'attention' up to 12 months of follow-up (beta-coefficient, -0.273 [95% CI, -0.436 to -0.109]) and 'executive function' after 12 months. Higher hs-cTnT was associated with the global SVD score (adjusted odds ratio, 1.95 [95% CI, 1.27-3.00]) and the white matter hyperintensities and lacune subscores.In patients with stroke, hs-cTnT is associated with a higher burden of SVD markers and cognitive function in domains linked to vascular cognitive impairment.URL: https://www.clinicaltrials.gov; Unique identifier: NCT01334749.
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650 _ 7 |a acute stroke
|2 Other
650 _ 7 |a cardiac troponin
|2 Other
650 _ 7 |a cognitive impairment
|2 Other
650 _ 7 |a heart and brain axis
|2 Other
650 _ 7 |a Troponin T
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Troponin T
|2 MeSH
650 _ 2 |a Prospective Studies
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: complications
|2 MeSH
650 _ 2 |a Stroke: diagnosis
|2 MeSH
650 _ 2 |a Stroke: epidemiology
|2 MeSH
650 _ 2 |a Stroke: complications
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: diagnosis
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: epidemiology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: etiology
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: epidemiology
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: complications
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Dementia
|2 MeSH
700 1 _ |a Nolte, Christian
|0 P:(DE-2719)9000234
|b 1
700 1 _ |a Liman, Thomas G
|0 P:(DE-2719)9000189
|b 2
700 1 _ |a Hellwig, Simon
|0 0000-0002-6925-4768
|b 3
700 1 _ |a Riegler, Christoph
|0 0000-0002-2478-3500
|b 4
700 1 _ |a Scheitz, Jan F
|0 P:(DE-2719)9001514
|b 5
700 1 _ |a Georgakis, Marios K
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Fang, Rong
|0 P:(DE-HGF)0
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700 1 _ |a Bode, Felix
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700 1 _ |a Petzold, Gabor C
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700 1 _ |a Hermann, Peter
|0 P:(DE-2719)2812183
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700 1 _ |a Zerr, Inga
|0 P:(DE-2719)2000058
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700 1 _ |a Görtler, Michael
|0 P:(DE-2719)2811292
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700 1 _ |a Bernkopf, Kathleen
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700 1 _ |a Wunderlich, Silke
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700 1 _ |a Dichgans, Martin
|0 P:(DE-2719)2000030
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700 1 _ |a Endres, Matthias
|0 P:(DE-2719)2811033
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700 1 _ |a , DEMDAS investigators
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700 1 _ |a Endres, Matthias
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700 1 _ |a Liman, Thomas G
|b 19
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700 1 _ |a Kerti, Lucia
|b 20
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700 1 _ |a Nolte, Christian H
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700 1 _ |a Wittenberg, Tatjana
|b 22
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700 1 _ |a Scheitz, Jan F
|b 23
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700 1 _ |a Prüß, Harald
|b 24
|e Contributor
700 1 _ |a Sperber, Pia Sophie
|b 25
|e Contributor
700 1 _ |a Nave, Alexander H
|b 26
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700 1 _ |a Ibaroule, Anna Kufner
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700 1 _ |a Petzold, Gabor
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700 1 _ |a Bode, Felix
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700 1 _ |a Stösser, Sebastian
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700 1 _ |a Meissner, Julius
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700 1 _ |a Ebrahimi, Taraneh
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700 1 _ |a Nordsiek, Julia
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700 1 _ |a Beckonert, Niklas
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700 1 _ |a Kindler, Christine
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700 1 _ |a Zerr, Inga
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700 1 _ |a Hermann, Peter
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700 1 _ |a Schmitz, Matthias
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700 1 _ |a Goebel, Stefan
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700 1 _ |a Bunck, Timothy
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700 1 _ |a Schütte-Schmidt, Julia
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700 1 _ |a Nuhn, Sabine
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700 1 _ |a Volpers, Corinna
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700 1 _ |a Dechent, Peter
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700 1 _ |a Bähr, Mathias
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700 1 _ |a Görtler, Michael
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700 1 _ |a Glanz, Wenzel
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700 1 _ |a Perosa, Valentina
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700 1 _ |a Dichgans, Martin
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700 1 _ |a Wollenweber, Frank
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700 1 _ |a Fang, Rong
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700 1 _ |a Janowitz, Daniel
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700 1 _ |a Waegemann, Karin
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700 1 _ |a Tiedt, Steffen
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700 1 _ |a Wunderlich, Silke
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700 1 _ |a Ikenberg, Benno
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700 1 _ |a Bernkopf, Kathleen
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700 1 _ |a Huber, Christiane
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700 1 _ |a Poppert, Holger
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700 1 _ |a Düring, Marco
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700 1 _ |a Araque Caballero, Miguel Ángel
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700 1 _ |a Gieserich, Benno
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700 1 _ |a Dewenter, Anna
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700 1 _ |a Dobisch, Laura
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700 1 _ |a Neumann, Katja
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700 1 _ |a Speck, Oliver
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700 1 _ |a Spottke, Annika
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700 1 _ |a Stöcker, Tony
|b 68
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700 1 _ |a Bartenstein, Peter
|b 69
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700 1 _ |a Wagner, Michael
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773 _ _ |a 10.1161/JAHA.123.033439
|g Vol. 13, no. 6, p. e033439
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