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@ARTICLE{Arboit:268721,
      author       = {Arboit, Alberto and Krautwald, Karla and Angenstein, Frank},
      title        = {{H}emodynamic responses in the rat hippocampus are
                      simultaneously controlled by at least two independently
                      acting neurovascular coupling mechanisms},
      journal      = {Journal of cerebral blood flow $\&$ metabolism},
      volume       = {44},
      number       = {6},
      issn         = {0271-678X},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DZNE-2024-00300},
      pages        = {896 - 910},
      year         = {2024},
      abstract     = {We combined electrical perforant pathway stimulation with
                      electrophysiological and fMRI recordings in the hippocampus
                      to investigate the effects of neuronal afterdischarges (nAD)
                      on subsequent fMRI BOLD signals in the presence of
                      isoflurane and medetomidine. These two drugs already alter
                      basal hemodynamics in the hippocampus, with isoflurane being
                      mildly vasodilatory and medetomidine being mildly
                      vasoconstrictive. The perforant pathway was stimulated once
                      for 8 seconds with either continuous 20 Hz pulses
                      (continuous stimulation) or 8 bursts of 20 high-frequency
                      pulses (burst stimulation). Burst stimulation in the
                      presence of medetomidine elicited long-lasting nAD that
                      coincided with a brief positive BOLD response and a
                      subsequent long-lasting decrease in BOLD signals. Under
                      isoflurane, this stimulation elicited only short-lasting nAD
                      and only a short-lasting decline in BOLD signals. In
                      contrast, continuous stimulation under isoflurane and
                      medetomidine caused a similar duration of nAD. Under
                      isoflurane, this caused only a sharp and prolonged decline
                      in BOLD signals, whereas under medetomidine, again, only a
                      brief positive BOLD response was elicited, followed by a
                      shorter and moderate decline in BOLD signals. Our results
                      suggest that nAD simultaneously activate different
                      neurovascular coupling mechanisms that then independently
                      alter local hemodynamics in the hippocampus, resulting in an
                      even more complex neurovascular coupling mechanism.},
      keywords     = {Animals / Neurovascular Coupling: physiology /
                      Neurovascular Coupling: drug effects / Isoflurane:
                      pharmacology / Hippocampus: physiology / Hippocampus: drug
                      effects / Hippocampus: blood supply / Medetomidine:
                      pharmacology / Male / Magnetic Resonance Imaging / Rats /
                      Hemodynamics: drug effects / Hemodynamics: physiology /
                      Electric Stimulation / Anesthetics, Inhalation: pharmacology
                      / Rats, Wistar / Perforant Pathway: physiology / Perforant
                      Pathway: drug effects / Cerebrovascular Circulation:
                      physiology / Cerebrovascular Circulation: drug effects /
                      BOLD-fMRI (Other) / dentate gyrus (Other) / in vivo
                      electrophysiology (Other) / negative BOLD response (Other) /
                      neuronal afterdischarges (Other)},
      cin          = {AG Angenstein},
      ddc          = {610},
      cid          = {I:(DE-2719)1310004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11318394},
      pubmed       = {pmid:38087890},
      doi          = {10.1177/0271678X231221039},
      url          = {https://pub.dzne.de/record/268721},
}