Home > Publications Database > Hemodynamic responses in the rat hippocampus are simultaneously controlled by at least two independently acting neurovascular coupling mechanisms > print

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037 _ _ |a DZNE-2024-00300
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100 1 _ |0 P:(DE-2719)2811871
|a Arboit, Alberto
|b 0
|e First author
245 _ _ |a Hemodynamic responses in the rat hippocampus are simultaneously controlled by at least two independently acting neurovascular coupling mechanisms
260 _ _ |a London
|b Sage
|c 2024
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520 _ _ |a We combined electrical perforant pathway stimulation with electrophysiological and fMRI recordings in the hippocampus to investigate the effects of neuronal afterdischarges (nAD) on subsequent fMRI BOLD signals in the presence of isoflurane and medetomidine. These two drugs already alter basal hemodynamics in the hippocampus, with isoflurane being mildly vasodilatory and medetomidine being mildly vasoconstrictive. The perforant pathway was stimulated once for 8 seconds with either continuous 20 Hz pulses (continuous stimulation) or 8 bursts of 20 high-frequency pulses (burst stimulation). Burst stimulation in the presence of medetomidine elicited long-lasting nAD that coincided with a brief positive BOLD response and a subsequent long-lasting decrease in BOLD signals. Under isoflurane, this stimulation elicited only short-lasting nAD and only a short-lasting decline in BOLD signals. In contrast, continuous stimulation under isoflurane and medetomidine caused a similar duration of nAD. Under isoflurane, this caused only a sharp and prolonged decline in BOLD signals, whereas under medetomidine, again, only a brief positive BOLD response was elicited, followed by a shorter and moderate decline in BOLD signals. Our results suggest that nAD simultaneously activate different neurovascular coupling mechanisms that then independently alter local hemodynamics in the hippocampus, resulting in an even more complex neurovascular coupling mechanism.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Neurovascular Coupling: physiology
|2 MeSH
650 _ 2 |a Neurovascular Coupling: drug effects
|2 MeSH
650 _ 2 |a Isoflurane: pharmacology
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Hippocampus: drug effects
|2 MeSH
650 _ 2 |a Hippocampus: blood supply
|2 MeSH
650 _ 2 |a Medetomidine: pharmacology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Hemodynamics: drug effects
|2 MeSH
650 _ 2 |a Hemodynamics: physiology
|2 MeSH
650 _ 2 |a Electric Stimulation
|2 MeSH
650 _ 2 |a Anesthetics, Inhalation: pharmacology
|2 MeSH
650 _ 2 |a Rats, Wistar
|2 MeSH
650 _ 2 |a Perforant Pathway: physiology
|2 MeSH
650 _ 2 |a Perforant Pathway: drug effects
|2 MeSH
650 _ 2 |a Cerebrovascular Circulation: physiology
|2 MeSH
650 _ 2 |a Cerebrovascular Circulation: drug effects
|2 MeSH
650 _ 7 |a BOLD-fMRI
|2 Other
650 _ 7 |a dentate gyrus
|2 Other
650 _ 7 |a in vivo electrophysiology
|2 Other
650 _ 7 |a negative BOLD response
|2 Other
650 _ 7 |a neuronal afterdischarges
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700 1 _ |0 P:(DE-2719)2278716
|a Krautwald, Karla
|b 1
700 1 _ |0 P:(DE-2719)2810456
|a Angenstein, Frank
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|t Journal of cerebral blood flow & metabolism
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