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| 001 | 268729 | ||
| 005 | 20240611120549.0 | ||
| 024 | 7 | _ | |a 10.1084/jem.20221190 |2 doi |
| 024 | 7 | _ | |a pmid:38517332 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC10959724 |2 pmc |
| 024 | 7 | _ | |a 0022-1007 |2 ISSN |
| 024 | 7 | _ | |a 1540-9358 |2 ISSN |
| 024 | 7 | _ | |a 1540-9538 |2 ISSN |
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| 037 | _ | _ | |a DZNE-2024-00305 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Brenner, David |0 P:(DE-2719)9002137 |b 0 |u dzne |
| 245 | _ | _ | |a A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice. |
| 260 | _ | _ | |a New York, NY |c 2024 |b Rockefeller Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1718023951_5322 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Heterozygous mutations in the TBK1 gene can cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The majority of TBK1-ALS/FTD patients carry deleterious loss-of-expression mutations, and it is still unclear which TBK1 function leads to neurodegeneration. We investigated the impact of the pathogenic TBK1 missense variant p.E696K, which does not abolish protein expression, but leads to a selective loss of TBK1 binding to the autophagy adaptor protein and TBK1 substrate optineurin. Using organelle-specific proteomics, we found that in a knock-in mouse model and human iPSC-derived motor neurons, the p.E696K mutation causes presymptomatic onset of autophagolysosomal dysfunction in neurons precipitating the accumulation of damaged lysosomes. This is followed by a progressive, age-dependent motor neuron disease. Contrary to the phenotype of mice with full Tbk1 knock-out, RIPK/TNF-α-dependent hepatic, neuronal necroptosis, and overt autoinflammation were not detected. Our in vivo results indicate autophagolysosomal dysfunction as a trigger for neurodegeneration and a promising therapeutic target in TBK1-ALS/FTD. |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 0 |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Protein Serine-Threonine Kinases |0 EC 2.7.11.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a TBK1 protein, human |0 EC 2.7.11.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Tbk1 protein, mouse |0 EC 2.7.1.- |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Amyotrophic Lateral Sclerosis: pathology |2 MeSH |
| 650 | _ | 2 | |a Frontotemporal Dementia: genetics |2 MeSH |
| 650 | _ | 2 | |a Frontotemporal Dementia: metabolism |2 MeSH |
| 650 | _ | 2 | |a Frontotemporal Dementia: pathology |2 MeSH |
| 650 | _ | 2 | |a Motor Neurons: pathology |2 MeSH |
| 650 | _ | 2 | |a Mutation |2 MeSH |
| 650 | _ | 2 | |a Neuroinflammatory Diseases |2 MeSH |
| 650 | _ | 2 | |a Phosphorylation |2 MeSH |
| 650 | _ | 2 | |a Protein Serine-Threonine Kinases: genetics |2 MeSH |
| 650 | _ | 2 | |a Protein Serine-Threonine Kinases: metabolism |2 MeSH |
| 700 | 1 | _ | |a Sieverding, Kirsten |0 P:(DE-2719)9002569 |b 1 |
| 700 | 1 | _ | |a Srinidhi, Jahnavi |0 0009-0003-8416-2276 |b 2 |
| 700 | 1 | _ | |a Zellner, Susanne |0 0000-0002-8523-824X |b 3 |
| 700 | 1 | _ | |a Secker, Christopher |0 P:(DE-2719)9000380 |b 4 |
| 700 | 1 | _ | |a Yilmaz, Rüstem |0 0000-0002-4261-5236 |b 5 |
| 700 | 1 | _ | |a Dyckow, Julia |0 0000-0003-1423-9322 |b 6 |
| 700 | 1 | _ | |a Amr, Shady |0 0009-0000-1597-1510 |b 7 |
| 700 | 1 | _ | |a Ponomarenko, Anna |0 0009-0009-9223-9310 |b 8 |
| 700 | 1 | _ | |a Tunaboylu, Esra |0 0009-0002-4266-4449 |b 9 |
| 700 | 1 | _ | |a Douahem, Yasmin |0 0009-0004-7079-7120 |b 10 |
| 700 | 1 | _ | |a Schlag, Joana S |0 0009-0005-2001-4121 |b 11 |
| 700 | 1 | _ | |a Rodriguez Martinez, Lucia |0 P:(DE-2719)9001702 |b 12 |u dzne |
| 700 | 1 | _ | |a Kislinger, Georg |0 P:(DE-2719)9000614 |b 13 |
| 700 | 1 | _ | |a Niemann, Cornelia |0 P:(DE-2719)9001883 |b 14 |u dzne |
| 700 | 1 | _ | |a Nalbach, Karsten |0 P:(DE-2719)9002811 |b 15 |u dzne |
| 700 | 1 | _ | |a Ruf, Wolfgang P |0 P:(DE-2719)9001522 |b 16 |
| 700 | 1 | _ | |a Uhl, Jonathan |0 0009-0005-1754-173X |b 17 |
| 700 | 1 | _ | |a Hollenbeck, Johanna |0 0009-0009-9877-7822 |b 18 |
| 700 | 1 | _ | |a Schirmer, Lucas |0 0000-0001-7142-4116 |b 19 |
| 700 | 1 | _ | |a Catanese, Alberto |0 P:(DE-2719)9001873 |b 20 |u dzne |
| 700 | 1 | _ | |a Lobsiger, Christian S |0 0000-0002-4313-010X |b 21 |
| 700 | 1 | _ | |a Danzer, Karin M |0 P:(DE-2719)9001513 |b 22 |
| 700 | 1 | _ | |a Yilmazer-Hanke, Deniz |0 0000-0003-1483-0286 |b 23 |
| 700 | 1 | _ | |a Münch, Christian |0 0000-0003-3832-090X |b 24 |
| 700 | 1 | _ | |a Koch, Philipp |0 P:(DE-2719)9002165 |b 25 |u dzne |
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| 700 | 1 | _ | |a Behrends, Christian |0 0000-0002-9184-7607 |b 28 |
| 700 | 1 | _ | |a Parlato, Rosanna |0 0000-0001-6682-9645 |b 29 |
| 700 | 1 | _ | |a Weishaupt, Jochen H |0 P:(DE-2719)9000455 |b 30 |
| 773 | _ | _ | |a 10.1084/jem.20221190 |g Vol. 221, no. 5, p. e20221190 |0 PERI:(DE-600)1477240-1 |n 5 |p e20221190 |t Journal of experimental medicine |v 221 |y 2024 |x 0022-1007 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/268729/files/DZNE-2024-00305%20SUP.zip |
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