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000268784 1001_ $$aNikbakht, Negar$$b0
000268784 245__ $$aEfficient encoding of aversive location by CA3 long-range projections.
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000268784 520__ $$aMemorizing locations that are harmful or dangerous is a key capability of all organisms and requires an integration of affective and spatial information. In mammals, the dorsal hippocampus mainly processes spatial information, while the intermediate to ventral hippocampal divisions receive affective information via the amygdala. However, how spatial and aversive information is integrated is currently unknown. To address this question, we recorded the activity of hippocampal long-range CA3 axons at single-axon resolution in mice forming an aversive spatial memory. We show that intermediate CA3 to dorsal CA3 (i-dCA3) projections rapidly overrepresent areas preceding the location of an aversive stimulus due to a spatially selective addition of new place-coding axons followed by spatially non-specific stabilization. This sequence significantly improves the encoding of location by the i-dCA3 axon population. These results suggest that i-dCA3 axons transmit a precise, denoised, and stable signal indicating imminent danger to the dorsal hippocampus.
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000268784 650_7 $$2Other$$aCA3 subfield
000268784 650_7 $$2Other$$aCP: Neuroscience
000268784 650_7 $$2Other$$aaversive learning
000268784 650_7 $$2Other$$adorsal hippocampus
000268784 650_7 $$2Other$$aplace coding
000268784 650_7 $$2Other$$aventral hippocampus
000268784 650_2 $$2MeSH$$aMice
000268784 650_2 $$2MeSH$$aAnimals
000268784 650_2 $$2MeSH$$aHippocampus
000268784 650_2 $$2MeSH$$aAxons
000268784 650_2 $$2MeSH$$aSpatial Memory
000268784 650_2 $$2MeSH$$aMammals
000268784 7001_ $$aPofahl, Martin$$b1
000268784 7001_ $$aMiguel-López, Albert$$b2
000268784 7001_ $$aKamali, Fateme$$b3
000268784 7001_ $$aTchumatchenko, Tatjana$$b4
000268784 7001_ $$0P:(DE-2719)2000044$$aBeck, Heinz$$b5$$eLast author$$udzne
000268784 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2024.113957$$gVol. 43, no. 3, p. 113957 -$$n3$$p113957$$tCell reports$$v43$$x2211-1247$$y2024
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