TY  - JOUR
AU  - Nikbakht, Negar
AU  - Pofahl, Martin
AU  - Miguel-López, Albert
AU  - Kamali, Fateme
AU  - Tchumatchenko, Tatjana
AU  - Beck, Heinz
TI  - Efficient encoding of aversive location by CA3 long-range projections.
JO  - Cell reports
VL  - 43
IS  - 3
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - DZNE-2024-00327
SP  - 113957
PY  - 2024
AB  - Memorizing locations that are harmful or dangerous is a key capability of all organisms and requires an integration of affective and spatial information. In mammals, the dorsal hippocampus mainly processes spatial information, while the intermediate to ventral hippocampal divisions receive affective information via the amygdala. However, how spatial and aversive information is integrated is currently unknown. To address this question, we recorded the activity of hippocampal long-range CA3 axons at single-axon resolution in mice forming an aversive spatial memory. We show that intermediate CA3 to dorsal CA3 (i-dCA3) projections rapidly overrepresent areas preceding the location of an aversive stimulus due to a spatially selective addition of new place-coding axons followed by spatially non-specific stabilization. This sequence significantly improves the encoding of location by the i-dCA3 axon population. These results suggest that i-dCA3 axons transmit a precise, denoised, and stable signal indicating imminent danger to the dorsal hippocampus.
KW  - Mice
KW  - Animals
KW  - Hippocampus
KW  - Axons
KW  - Spatial Memory
KW  - Mammals
KW  - CA3 subfield (Other)
KW  - CP: Neuroscience (Other)
KW  - aversive learning (Other)
KW  - dorsal hippocampus (Other)
KW  - place coding (Other)
KW  - ventral hippocampus (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38489262
DO  - DOI:10.1016/j.celrep.2024.113957
UR  - https://pub.dzne.de/record/268784
ER  -