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@ARTICLE{Nikbakht:268784,
      author       = {Nikbakht, Negar and Pofahl, Martin and Miguel-López,
                      Albert and Kamali, Fateme and Tchumatchenko, Tatjana and
                      Beck, Heinz},
      title        = {{E}fficient encoding of aversive location by {CA}3
                      long-range projections.},
      journal      = {Cell reports},
      volume       = {43},
      number       = {3},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2024-00327},
      pages        = {113957},
      year         = {2024},
      abstract     = {Memorizing locations that are harmful or dangerous is a key
                      capability of all organisms and requires an integration of
                      affective and spatial information. In mammals, the dorsal
                      hippocampus mainly processes spatial information, while the
                      intermediate to ventral hippocampal divisions receive
                      affective information via the amygdala. However, how spatial
                      and aversive information is integrated is currently unknown.
                      To address this question, we recorded the activity of
                      hippocampal long-range CA3 axons at single-axon resolution
                      in mice forming an aversive spatial memory. We show that
                      intermediate CA3 to dorsal CA3 (i-dCA3) projections rapidly
                      overrepresent areas preceding the location of an aversive
                      stimulus due to a spatially selective addition of new
                      place-coding axons followed by spatially non-specific
                      stabilization. This sequence significantly improves the
                      encoding of location by the i-dCA3 axon population. These
                      results suggest that i-dCA3 axons transmit a precise,
                      denoised, and stable signal indicating imminent danger to
                      the dorsal hippocampus.},
      keywords     = {Mice / Animals / Hippocampus / Axons / Spatial Memory /
                      Mammals / CA3 subfield (Other) / CP: Neuroscience (Other) /
                      aversive learning (Other) / dorsal hippocampus (Other) /
                      place coding (Other) / ventral hippocampus (Other)},
      cin          = {Bonn common},
      ddc          = {610},
      cid          = {I:(DE-2719)6000011},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38489262},
      doi          = {10.1016/j.celrep.2024.113957},
      url          = {https://pub.dzne.de/record/268784},
}