Home > Publications Database > Efficient encoding of aversive location by CA3 long-range projections. > print

001     268784
005     20250603100721.0
024 7 _ |a 10.1016/j.celrep.2024.113957
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037 _ _ |a DZNE-2024-00327
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082 _ _ |a 610
100 1 _ |a Nikbakht, Negar
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245 _ _ |a Efficient encoding of aversive location by CA3 long-range projections.
260 _ _ |a [New York, NY]
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520 _ _ |a Memorizing locations that are harmful or dangerous is a key capability of all organisms and requires an integration of affective and spatial information. In mammals, the dorsal hippocampus mainly processes spatial information, while the intermediate to ventral hippocampal divisions receive affective information via the amygdala. However, how spatial and aversive information is integrated is currently unknown. To address this question, we recorded the activity of hippocampal long-range CA3 axons at single-axon resolution in mice forming an aversive spatial memory. We show that intermediate CA3 to dorsal CA3 (i-dCA3) projections rapidly overrepresent areas preceding the location of an aversive stimulus due to a spatially selective addition of new place-coding axons followed by spatially non-specific stabilization. This sequence significantly improves the encoding of location by the i-dCA3 axon population. These results suggest that i-dCA3 axons transmit a precise, denoised, and stable signal indicating imminent danger to the dorsal hippocampus.
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650 _ 7 |a CA3 subfield
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650 _ 7 |a CP: Neuroscience
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650 _ 7 |a aversive learning
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650 _ 7 |a dorsal hippocampus
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650 _ 7 |a place coding
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650 _ 7 |a ventral hippocampus
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650 _ 2 |a Mice
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650 _ 2 |a Animals
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650 _ 2 |a Hippocampus
|2 MeSH
650 _ 2 |a Axons
|2 MeSH
650 _ 2 |a Spatial Memory
|2 MeSH
650 _ 2 |a Mammals
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700 1 _ |a Pofahl, Martin
|b 1
700 1 _ |a Miguel-López, Albert
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700 1 _ |a Kamali, Fateme
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700 1 _ |a Tchumatchenko, Tatjana
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700 1 _ |a Beck, Heinz
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773 _ _ |a 10.1016/j.celrep.2024.113957
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856 4 _ |u https://pub.dzne.de/record/268784/files/DZNE-2024-00327%20SUP.zip
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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