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000268838 037__ $$aDZNE-2024-00342
000268838 041__ $$aEnglish
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000268838 1001_ $$aBasheer, Neha$$b0
000268838 245__ $$aShaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
000268838 260__ $$aLondon$$bBiomed Central$$c2024
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000268838 520__ $$aThe transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.
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000268838 650_2 $$2MeSH$$aAnimals
000268838 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000268838 650_2 $$2MeSH$$aNeurofibrillary Tangles: pathology
000268838 650_2 $$2MeSH$$aDisease Models, Animal
000268838 650_2 $$2MeSH$$aTauopathies: pathology
000268838 650_2 $$2MeSH$$atau Proteins: metabolism
000268838 650_2 $$2MeSH$$aBrain: pathology
000268838 650_7 $$2NLM Chemicals$$atau Proteins
000268838 650_7 $$2Other$$aAggregation
000268838 650_7 $$2Other$$aAnimal models
000268838 650_7 $$2Other$$aNeurofibrillary tangles
000268838 650_7 $$2Other$$aPropagation
000268838 650_7 $$2Other$$aSpreading
000268838 650_7 $$2Other$$aTau protein
000268838 7001_ $$aBuee, Luc$$b1
000268838 7001_ $$aBrion, Jean-Pierre$$b2
000268838 7001_ $$aSmolek, Tomas$$b3
000268838 7001_ $$aMuhammadi, Muhammad Khalid$$b4
000268838 7001_ $$aHritz, Jozef$$b5
000268838 7001_ $$aHromadka, Tomas$$b6
000268838 7001_ $$aDewachter, Ilse$$b7
000268838 7001_ $$0P:(DE-2719)2812695$$aWegmann, Susanne$$b8$$udzne
000268838 7001_ $$aLandrieu, Isabelle$$b9
000268838 7001_ $$aNovak, Petr$$b10
000268838 7001_ $$aMudher, Amritpal$$b11
000268838 7001_ $$aZilka, Norbert$$b12
000268838 773__ $$0PERI:(DE-600)2715589-4$$a10.1186/s40478-024-01748-5$$gVol. 12, no. 1, p. 52$$n1$$p52$$tActa Neuropathologica Communications$$v12$$x2051-5960$$y2024
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