TY  - JOUR
AU  - Basheer, Neha
AU  - Buee, Luc
AU  - Brion, Jean-Pierre
AU  - Smolek, Tomas
AU  - Muhammadi, Muhammad Khalid
AU  - Hritz, Jozef
AU  - Hromadka, Tomas
AU  - Dewachter, Ilse
AU  - Wegmann, Susanne
AU  - Landrieu, Isabelle
AU  - Novak, Petr
AU  - Mudher, Amritpal
AU  - Zilka, Norbert
TI  - Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
JO  - Acta Neuropathologica Communications
VL  - 12
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DZNE-2024-00342
SP  - 52
PY  - 2024
AB  - The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.
KW  - Animals
KW  - Alzheimer Disease: pathology
KW  - Neurofibrillary Tangles: pathology
KW  - Disease Models, Animal
KW  - Tauopathies: pathology
KW  - tau Proteins: metabolism
KW  - Brain: pathology
KW  - tau Proteins (NLM Chemicals)
KW  - Aggregation (Other)
KW  - Animal models (Other)
KW  - Neurofibrillary tangles (Other)
KW  - Propagation (Other)
KW  - Spreading (Other)
KW  - Tau protein (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38576010
C2  - pmc:PMC10993623
DO  - DOI:10.1186/s40478-024-01748-5
UR  - https://pub.dzne.de/record/268838
ER  -