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@ARTICLE{Basheer:268838,
      author       = {Basheer, Neha and Buee, Luc and Brion, Jean-Pierre and
                      Smolek, Tomas and Muhammadi, Muhammad Khalid and Hritz,
                      Jozef and Hromadka, Tomas and Dewachter, Ilse and Wegmann,
                      Susanne and Landrieu, Isabelle and Novak, Petr and Mudher,
                      Amritpal and Zilka, Norbert},
      title        = {{S}haping the future of preclinical development of
                      successful disease-modifying drugs against {A}lzheimer's
                      disease: a systematic review of tau propagation models.},
      journal      = {Acta Neuropathologica Communications},
      volume       = {12},
      number       = {1},
      issn         = {2051-5960},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DZNE-2024-00342},
      pages        = {52},
      year         = {2024},
      abstract     = {The transcellular propagation of the aberrantly modified
                      protein tau along the functional brain network is a key
                      hallmark of Alzheimer's disease and related tauopathies.
                      Inoculation-based tau propagation models can recapitulate
                      the stereotypical spread of tau and reproduce various types
                      of tau inclusions linked to specific tauopathy, albeit with
                      varying degrees of fidelity. With this systematic review, we
                      underscore the significance of judicious selection and
                      meticulous functional, biochemical, and biophysical
                      characterization of various tau inocula. Furthermore, we
                      highlight the necessity of choosing suitable animal models
                      and inoculation sites, along with the critical need for
                      validation of fibrillary pathology using confirmatory
                      staining, to accurately recapitulate disease-specific
                      inclusions. As a practical guide, we put forth a framework
                      for establishing a benchmark of inoculation-based tau
                      propagation models that holds promise for use in preclinical
                      testing of disease-modifying drugs.},
      subtyp        = {Review Article},
      keywords     = {Animals / Alzheimer Disease: pathology / Neurofibrillary
                      Tangles: pathology / Disease Models, Animal / Tauopathies:
                      pathology / tau Proteins: metabolism / Brain: pathology /
                      tau Proteins (NLM Chemicals) / Aggregation (Other) / Animal
                      models (Other) / Neurofibrillary tangles (Other) /
                      Propagation (Other) / Spreading (Other) / Tau protein
                      (Other)},
      cin          = {AG Wegmann},
      ddc          = {610},
      cid          = {I:(DE-2719)1810006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38576010},
      pmc          = {pmc:PMC10993623},
      doi          = {10.1186/s40478-024-01748-5},
      url          = {https://pub.dzne.de/record/268838},
}