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000268839 1001_ $$0P:(DE-2719)2810548$$aZocher, Sara$$b0$$eFirst author
000268839 245__ $$aLifelong persistence of nuclear RNAs in the mouse brain.
000268839 260__ $$aWashington, DC$$bAmerican Association for the Advancement of Science$$c2024
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000268839 520__ $$aGenomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.
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000268839 650_2 $$2MeSH$$aAnimals
000268839 650_2 $$2MeSH$$aMice
000268839 650_2 $$2MeSH$$aBrain: metabolism
000268839 650_2 $$2MeSH$$aChromatin
000268839 650_2 $$2MeSH$$aGene Expression Regulation
000268839 650_2 $$2MeSH$$aHeterochromatin: genetics
000268839 650_2 $$2MeSH$$aRNA, Nuclear: genetics
000268839 650_7 $$2NLM Chemicals$$aChromatin
000268839 650_7 $$2NLM Chemicals$$aHeterochromatin
000268839 650_7 $$2NLM Chemicals$$aRNA, Nuclear
000268839 7001_ $$00009-0007-7606-187X$$aMcCloskey, Asako$$b1
000268839 7001_ $$0P:(DE-2719)9001964$$aKarasinsky, Anne$$b2$$udzne
000268839 7001_ $$aSchulte, Roberta$$b3
000268839 7001_ $$00000-0001-7295-4549$$aFriedrich, Ulrike$$b4
000268839 7001_ $$00000-0002-3274-7163$$aLesche, Mathias$$b5
000268839 7001_ $$0P:(DE-2719)2811674$$aRund, Nicole$$b6$$udzne
000268839 7001_ $$00000-0002-0938-4106$$aGage, Fred H$$b7
000268839 7001_ $$00000-0002-2111-992X$$aHetzer, Martin W$$b8
000268839 7001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b9$$eLast author
000268839 773__ $$0PERI:(DE-600)2066996-3$$a10.1126/science.adf3481$$gVol. 384, no. 6691, p. 53 - 59$$n6691$$p53 - 59$$tScience$$v384$$x0036-8075$$y2024
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