TY  - JOUR
AU  - Zocher, Sara
AU  - McCloskey, Asako
AU  - Karasinsky, Anne
AU  - Schulte, Roberta
AU  - Friedrich, Ulrike
AU  - Lesche, Mathias
AU  - Rund, Nicole
AU  - Gage, Fred H
AU  - Hetzer, Martin W
AU  - Toda, Tomohisa
TI  - Lifelong persistence of nuclear RNAs in the mouse brain.
JO  - Science
VL  - 384
IS  - 6691
SN  - 0036-8075
CY  - Washington, DC
PB  - American Association for the Advancement of Science
M1  - DZNE-2024-00343
SP  - 53 - 59
PY  - 2024
N1  - ISSN 1095-9203 not unique: **3 hits**.
AB  - Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.
KW  - Animals
KW  - Mice
KW  - Brain: metabolism
KW  - Chromatin
KW  - Gene Expression Regulation
KW  - Heterochromatin: genetics
KW  - RNA, Nuclear: genetics
KW  - Chromatin (NLM Chemicals)
KW  - Heterochromatin (NLM Chemicals)
KW  - RNA, Nuclear (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC7615865
C6  - pmid:38574132
DO  - DOI:10.1126/science.adf3481
UR  - https://pub.dzne.de/record/268839
ER  -