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@ARTICLE{Zocher:268839,
      author       = {Zocher, Sara and McCloskey, Asako and Karasinsky, Anne and
                      Schulte, Roberta and Friedrich, Ulrike and Lesche, Mathias
                      and Rund, Nicole and Gage, Fred H and Hetzer, Martin W and
                      Toda, Tomohisa},
      title        = {{L}ifelong persistence of nuclear {RNA}s in the mouse
                      brain.},
      journal      = {Science},
      volume       = {384},
      number       = {6691},
      issn         = {0036-8075},
      address      = {Washington, DC},
      publisher    = {American Association for the Advancement of Science},
      reportid     = {DZNE-2024-00343},
      pages        = {53 - 59},
      year         = {2024},
      note         = {ISSN 1095-9203 not unique: **3 hits**.},
      abstract     = {Genomic DNA that resides in the nuclei of mammalian neurons
                      can be as old as the organism itself. The life span of
                      nuclear RNAs, which are critical for proper chromatin
                      architecture and transcription regulation, has not been
                      determined in adult tissues. In this work, we identified and
                      characterized nuclear RNAs that do not turn over for at
                      least 2 years in a subset of postnatally born cells in the
                      mouse brain. These long-lived RNAs were stably retained in
                      nuclei in a neural cell type-specific manner and were
                      required for the maintenance of heterochromatin. Thus, the
                      life span of neural cells may depend on both the molecular
                      longevity of DNA for the storage of genetic information and
                      also the extreme stability of RNA for the functional
                      organization of chromatin.},
      keywords     = {Animals / Mice / Brain: metabolism / Chromatin / Gene
                      Expression Regulation / Heterochromatin: genetics / RNA,
                      Nuclear: genetics / Chromatin (NLM Chemicals) /
                      Heterochromatin (NLM Chemicals) / RNA, Nuclear (NLM
                      Chemicals)},
      cin          = {AG Toda},
      ddc          = {500},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7615865},
      pubmed       = {pmid:38574132},
      doi          = {10.1126/science.adf3481},
      url          = {https://pub.dzne.de/record/268839},
}