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@ARTICLE{Joue:268844,
      author       = {Joue, Gina and Navarro-Schröder, Tobias and Achtzehn,
                      Johannes and Moffat, Scott and Hennies, Nora and Fuß,
                      Johannes and Döller, Christian and Wolbers, Thomas and
                      Sommer, Tobias},
      title        = {{E}ffects of estrogen on spatial navigation and memory.},
      journal      = {Psychopharmacology},
      volume       = {241},
      number       = {5},
      issn         = {0033-3158},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {DZNE-2024-00348},
      pages        = {1037 - 1063},
      year         = {2024},
      abstract     = {Animal studies suggest that the so-called 'female' hormone
                      estrogen enhances spatial navigation and memory. This
                      contradicts the observation that males generally out-perform
                      females in spatial navigation and tasks involving spatial
                      memory. A closer look at the vast number of studies actually
                      reveals that performance differences are not so clear.To
                      help clarify the unclear performance differences between men
                      and women and the role of estrogen, we attempted to isolate
                      organizational from activational effects of estrogen on
                      spatial navigation and memory.In a double-blind,
                      placebo-controlled study, we tested the effects of orally
                      administered estradiol valerate (E2V) in healthy, young
                      women in their low-hormone menstrual cycle phase, compared
                      to healthy, young men. Participants performed several
                      first-person, environmentally rich, 3-D computer games
                      inspired by spatial navigation and memory paradigms in
                      animal research.We found navigation behavior suggesting that
                      sex effects dominated any E2 effects with men performing
                      better with allocentric strategies and women with egocentric
                      strategies. Increased E2 levels did not lead to general
                      improvements in spatial ability in either sex but to
                      behavioral changes reflecting navigation
                      flexibility.Estrogen-driven differences in spatial cognition
                      might be better characterized on a spectrum of navigation
                      flexibility rather than by categorical performance measures
                      or skills.},
      keywords     = {Animals / Female / Humans / Male / Estradiol: pharmacology
                      / Estrogens: pharmacology / Spatial Memory / Spatial
                      Navigation / Double-Blind Method / Estradiol (NLM Chemicals)
                      / Estrogen (Other) / Gender differences (Other) / Sex
                      differences (Other) / Spatial memory (Other) / Spatial
                      navigation (Other) / Estrogens (NLM Chemicals)},
      cin          = {AG Wolbers},
      ddc          = {004},
      cid          = {I:(DE-2719)1310002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11031496},
      pubmed       = {pmid:38407638},
      doi          = {10.1007/s00213-024-06539-3},
      url          = {https://pub.dzne.de/record/268844},
}