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000268845 245__ $$aEntorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease.
000268845 260__ $$aHoboken, NJ$$bWiley$$c2024
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000268845 520__ $$aEntorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)-based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD.We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function.Midlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi-risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior-medial EC.Altered PI may represent the transition point from at-risk state to disease manifestation in AD, prior to impairment in other cognitive domains.
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000268845 650_7 $$2Other$$aAlzheimer's disease
000268845 650_7 $$2Other$$aentorhinal cortex
000268845 650_7 $$2Other$$apath integration
000268845 650_7 $$2Other$$apreclinical
000268845 650_7 $$2Other$$avirtual reality
000268845 650_2 $$2MeSH$$aAdult
000268845 650_2 $$2MeSH$$aHumans
000268845 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000268845 650_2 $$2MeSH$$aEntorhinal Cortex: pathology
000268845 650_2 $$2MeSH$$aBrain: pathology
000268845 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000268845 7001_ $$aPope, Marianna$$b1
000268845 7001_ $$00000-0002-0404-4399$$aRua, Catarina$$b2
000268845 7001_ $$00000-0002-0712-2639$$aHenson, Richard$$b3
000268845 7001_ $$00000-0001-7868-6178$$aJi, Zilong$$b4
000268845 7001_ $$00000-0003-0646-6584$$aBurgess, Neil$$b5
000268845 7001_ $$00000-0003-1275-1197$$aRodgers, Christopher T$$b6
000268845 7001_ $$0P:(DE-2719)2810620$$aStangl, Matthias$$b7
000268845 7001_ $$00000-0001-8287-346X$$aDounavi, Maria-Eleni$$b8
000268845 7001_ $$00000-0003-1554-525X$$aCastegnaro, Andrea$$b9
000268845 7001_ $$00000-0001-6813-8493$$aKoychev, Ivan$$b10
000268845 7001_ $$00000-0002-1897-0780$$aMalhotra, Paresh$$b11
000268845 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b12$$udzne
000268845 7001_ $$00000-0002-0688-8982$$aRitchie, Karen$$b13
000268845 7001_ $$00000-0002-6202-6906$$aRitchie, Craig W$$b14
000268845 7001_ $$aO'Brien, John$$b15
000268845 7001_ $$00000-0002-6347-3986$$aSu, Li$$b16
000268845 7001_ $$aChan, Dennis$$b17
000268845 7001_ $$aProgramme, PREVENT Dementia Research$$b18$$eCollaboration Author
000268845 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.13733$$gp. alz.13733$$n4$$p2779 - 2793$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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