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@ARTICLE{Newton:268845,
      author       = {Newton, Coco and Pope, Marianna and Rua, Catarina and
                      Henson, Richard and Ji, Zilong and Burgess, Neil and
                      Rodgers, Christopher T and Stangl, Matthias and Dounavi,
                      Maria-Eleni and Castegnaro, Andrea and Koychev, Ivan and
                      Malhotra, Paresh and Wolbers, Thomas and Ritchie, Karen and
                      Ritchie, Craig W and O'Brien, John and Su, Li and Chan,
                      Dennis},
      collaboration = {Programme, PREVENT Dementia Research},
      title        = {{E}ntorhinal-based path integration selectively predicts
                      midlife risk of {A}lzheimer's disease.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {4},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-00349},
      pages        = {2779 - 2793},
      year         = {2024},
      abstract     = {Entorhinal cortex (EC) is the first cortical region to
                      exhibit neurodegeneration in Alzheimer's disease (AD),
                      associated with EC grid cell dysfunction. Given the role of
                      grid cells in path integration (PI)-based spatial behaviors,
                      we predicted that PI impairment would represent the first
                      behavioral change in adults at risk of AD.We compared
                      immersive virtual reality (VR) PI ability to other cognitive
                      domains in 100 asymptomatic midlife adults stratified by
                      hereditary and physiological AD risk factors. In some
                      participants, behavioral data were compared to 7T magnetic
                      resonance imaging (MRI) measures of brain structure and
                      function.Midlife PI impairments predicted both hereditary
                      and physiological AD risk, with no corresponding multi-risk
                      impairment in episodic memory or other spatial behaviors.
                      Impairments associated with altered functional MRI signal in
                      the posterior-medial EC.Altered PI may represent the
                      transition point from at-risk state to disease manifestation
                      in AD, prior to impairment in other cognitive domains.},
      keywords     = {Adult / Humans / Alzheimer Disease: pathology / Entorhinal
                      Cortex: pathology / Brain: pathology / Magnetic Resonance
                      Imaging: methods / Alzheimer's disease (Other) / entorhinal
                      cortex (Other) / path integration (Other) / preclinical
                      (Other) / virtual reality (Other)},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11032581},
      pubmed       = {pmid:38421123},
      doi          = {10.1002/alz.13733},
      url          = {https://pub.dzne.de/record/268845},
}