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001     268845
005     20240808164606.0
024 7 _ |a pmc:PMC11032581
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024 7 _ |a 10.1002/alz.13733
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024 7 _ |a pmid:38421123
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024 7 _ |a 1552-5260
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037 _ _ |a DZNE-2024-00349
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Newton, Coco
|0 0000-0002-0937-9673
|b 0
245 _ _ |a Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease.
260 _ _ |a Hoboken, NJ
|c 2024
|b Wiley
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520 _ _ |a Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)-based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD.We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function.Midlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi-risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior-medial EC.Altered PI may represent the transition point from at-risk state to disease manifestation in AD, prior to impairment in other cognitive domains.
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650 _ 7 |a Alzheimer's disease
|2 Other
650 _ 7 |a entorhinal cortex
|2 Other
650 _ 7 |a path integration
|2 Other
650 _ 7 |a preclinical
|2 Other
650 _ 7 |a virtual reality
|2 Other
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Entorhinal Cortex: pathology
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging: methods
|2 MeSH
700 1 _ |a Pope, Marianna
|b 1
700 1 _ |a Rua, Catarina
|0 0000-0002-0404-4399
|b 2
700 1 _ |a Henson, Richard
|0 0000-0002-0712-2639
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700 1 _ |a Ji, Zilong
|0 0000-0001-7868-6178
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700 1 _ |a Burgess, Neil
|0 0000-0003-0646-6584
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700 1 _ |a Rodgers, Christopher T
|0 0000-0003-1275-1197
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700 1 _ |a Stangl, Matthias
|0 P:(DE-2719)2810620
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700 1 _ |a Dounavi, Maria-Eleni
|0 0000-0001-8287-346X
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700 1 _ |a Castegnaro, Andrea
|0 0000-0003-1554-525X
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700 1 _ |a Koychev, Ivan
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700 1 _ |a Malhotra, Paresh
|0 0000-0002-1897-0780
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700 1 _ |a Wolbers, Thomas
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700 1 _ |a Ritchie, Karen
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700 1 _ |a Ritchie, Craig W
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700 1 _ |a O'Brien, John
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700 1 _ |a Su, Li
|0 0000-0002-6347-3986
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700 1 _ |a Chan, Dennis
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700 1 _ |a Programme, PREVENT Dementia Research
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773 _ _ |a 10.1002/alz.13733
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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