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000268859 037__ $$aDZNE-2024-00358
000268859 041__ $$aEnglish
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000268859 1001_ $$0P:(DE-2719)2810272$$aFlynn, Kevin$$b0$$eFirst author
000268859 245__ $$aThe cytoskeleton and neurite initiation.
000268859 260__ $$aAustin, Tex.$$bLandes Bioscience$$c2013
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000268859 520__ $$aNeurons begin their life as simple spheres, but can ultimately assume an elaborate morphology with numerous, highly arborized dendrites, and long axons. This is achieved via an astounding developmental progression which is dependent upon regulated assembly and dynamics of the cellular cytoskeleton. As neurites emerge out of the soma, neurons break their spherical symmetry and begin to acquire the morphological features that define their structure and function. Neurons regulate their cytoskeleton to achieve changes in cell shape, velocity, and direction as they migrate, extend neurites, and polarize. Of particular importance, the organization and dynamics of actin and microtubules directs the migration and morphogenesis of neurons. This review focuses on the regulation of intrinsic properties of the actin and microtubule cytoskeletons and how specific cytoskeletal structures and dynamics are associated with the earliest phase of neuronal morphogenesis—neuritogenesis.
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000268859 650_7 $$2NLM Chemicals$$aActins
000268859 650_2 $$2MeSH$$aActins: metabolism
000268859 650_2 $$2MeSH$$aAnimals
000268859 650_2 $$2MeSH$$aCytoskeleton: metabolism
000268859 650_2 $$2MeSH$$aHumans
000268859 650_2 $$2MeSH$$aMorphogenesis
000268859 650_2 $$2MeSH$$aNeurites: metabolism
000268859 650_2 $$2MeSH$$aNeurons: cytology
000268859 650_2 $$2MeSH$$aNeurons: metabolism
000268859 773__ $$0PERI:(DE-600)2628854-0$$a10.4161/bioa.26259$$gVol. 3, no. 4, p. 86 - 109$$n4$$p86 - 109$$tBioArchitecture$$v3$$x1949-0992$$y2013
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000268859 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810272$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
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000268859 9141_ $$y2013
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