TY  - JOUR
AU  - Flynn, Kevin
TI  - The cytoskeleton and neurite initiation.
JO  - BioArchitecture
VL  - 3
IS  - 4
SN  - 1949-0992
CY  - Austin, Tex.
PB  - Landes Bioscience
M1  - DZNE-2024-00358
SP  - 86 - 109
PY  - 2013
AB  - Neurons begin their life as simple spheres, but can ultimately assume an elaborate morphology with numerous, highly arborized dendrites, and long axons. This is achieved via an astounding developmental progression which is dependent upon regulated assembly and dynamics of the cellular cytoskeleton. As neurites emerge out of the soma, neurons break their spherical symmetry and begin to acquire the morphological features that define their structure and function. Neurons regulate their cytoskeleton to achieve changes in cell shape, velocity, and direction as they migrate, extend neurites, and polarize. Of particular importance, the organization and dynamics of actin and microtubules directs the migration and morphogenesis of neurons. This review focuses on the regulation of intrinsic properties of the actin and microtubule cytoskeletons and how specific cytoskeletal structures and dynamics are associated with the earliest phase of neuronal morphogenesis—neuritogenesis.
KW  - Actins: metabolism
KW  - Animals
KW  - Cytoskeleton: metabolism
KW  - Humans
KW  - Morphogenesis
KW  - Neurites: metabolism
KW  - Neurons: cytology
KW  - Neurons: metabolism
KW  - Actins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24002528
C2  - pmc:PMC4201609
DO  - DOI:10.4161/bioa.26259
UR  - https://pub.dzne.de/record/268859
ER  -