Home > Publications Database > The cytoskeleton and neurite initiation. > print

001     268859
005     20260107151727.0
024 7 _ |a 10.4161/bioa.26259
|2 doi
024 7 _ |a pmid:24002528
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024 7 _ |a pmc:PMC4201609
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024 7 _ |a 1949-0992
|2 ISSN
024 7 _ |a 1949-100X
|2 ISSN
024 7 _ |a altmetric:1775994
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037 _ _ |a DZNE-2024-00358
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Flynn, Kevin
|0 P:(DE-2719)2810272
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|e First author
245 _ _ |a The cytoskeleton and neurite initiation.
260 _ _ |a Austin, Tex.
|c 2013
|b Landes Bioscience
336 7 _ |a article
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336 7 _ |a Journal Article
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|x Review Article
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Neurons begin their life as simple spheres, but can ultimately assume an elaborate morphology with numerous, highly arborized dendrites, and long axons. This is achieved via an astounding developmental progression which is dependent upon regulated assembly and dynamics of the cellular cytoskeleton. As neurites emerge out of the soma, neurons break their spherical symmetry and begin to acquire the morphological features that define their structure and function. Neurons regulate their cytoskeleton to achieve changes in cell shape, velocity, and direction as they migrate, extend neurites, and polarize. Of particular importance, the organization and dynamics of actin and microtubules directs the migration and morphogenesis of neurons. This review focuses on the regulation of intrinsic properties of the actin and microtubule cytoskeletons and how specific cytoskeletal structures and dynamics are associated with the earliest phase of neuronal morphogenesis—neuritogenesis.
536 _ _ |a 351 - Brain Function (POF4-351)
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Actins
|2 NLM Chemicals
650 _ 2 |a Actins: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cytoskeleton: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Morphogenesis
|2 MeSH
650 _ 2 |a Neurites: metabolism
|2 MeSH
650 _ 2 |a Neurons: cytology
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
773 _ _ |a 10.4161/bioa.26259
|g Vol. 3, no. 4, p. 86 - 109
|0 PERI:(DE-600)2628854-0
|n 4
|p 86 - 109
|t BioArchitecture
|v 3
|y 2013
|x 1949-0992
856 4 _ |u https://pub.dzne.de/record/268859/files/DZNE-2024-00358_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/268859/files/DZNE-2024-00358_Restricted.pdf?subformat=pdfa
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909 C O |o oai:pub.dzne.de:268859
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
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913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
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914 1 _ |Y 2013
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920 1 _ |0 I:(DE-2719)1013002
|k AG Bradke
|l Axon Growth and Regeneration
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1013002
980 _ _ |a UNRESTRICTED

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