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000269000 0247_ $$2doi$$a10.1007/s12268-023-2066-9
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000269000 037__ $$aDZNE-2024-00434
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000269000 1001_ $$0P:(DE-2719)2812244$$aFengler, Sven$$b0$$eFirst author$$udzne
000269000 245__ $$aKünstliche Hirngefäße zur Identifikation hirngängiger Wirkstoffe
000269000 260__ $$aHeidelberg$$bSpektrum$$c2023
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000269000 520__ $$aDue to the regulatory function of the human blood-brain barrier (BBB), optimizing brain-targeting drugs for brain-penetration is a challenge in drug discovery. Therefore, the development of in vitro assays that mimic relevant properties of the BBB are in focus to better predict drug permeability in humans. This article describes human iPSC-derived brain endothelial microvessels in perfusable multi-chip plates that provide physiological properties of the BBB in a scalable format for screening.
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000269000 7001_ $$0P:(DE-2719)2810323$$aKurkowsky, Birgit$$b1$$udzne
000269000 7001_ $$aHeimlich, Gerd$$b2
000269000 7001_ $$0P:(DE-2719)2159508$$aFava, Eugenio$$b3$$udzne
000269000 7001_ $$0P:(DE-2719)2810245$$aDenner, Philip$$b4$$eLast author$$udzne
000269000 773__ $$0PERI:(DE-600)2203536-9$$a10.1007/s12268-023-2066-9$$gVol. 29, no. 7, p. 766 - 767$$n7$$p766 - 767$$tBiospektrum$$v29$$x0947-0867$$y2023
000269000 8564_ $$uhttps://pub.dzne.de/record/269000/files/DZNE-2024-00434.pdf
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