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@ARTICLE{Fengler:269000,
author = {Fengler, Sven and Kurkowsky, Birgit and Heimlich, Gerd and
Fava, Eugenio and Denner, Philip},
title = {{K}ünstliche {H}irngefäße zur {I}dentifikation
hirngängiger {W}irkstoffe},
journal = {Biospektrum},
volume = {29},
number = {7},
issn = {0947-0867},
address = {Heidelberg},
publisher = {Spektrum},
reportid = {DZNE-2024-00434},
pages = {766 - 767},
year = {2023},
abstract = {Due to the regulatory function of the human blood-brain
barrier (BBB), optimizing brain-targeting drugs for
brain-penetration is a challenge in drug discovery.
Therefore, the development of in vitro assays that mimic
relevant properties of the BBB are in focus to better
predict drug permeability in humans. This article describes
human iPSC-derived brain endothelial microvessels in
perfusable multi-chip plates that provide physiological
properties of the BBB in a scalable format for screening.},
cin = {LAT / AG Fava},
ddc = {540},
cid = {I:(DE-2719)1040190 / I:(DE-2719)1040000},
pnm = {899 - ohne Topic (POF4-899)},
pid = {G:(DE-HGF)POF4-899},
experiment = {EXP:(DE-2719)LAT-20190308},
typ = {PUB:(DE-HGF)16},
doi = {10.1007/s12268-023-2066-9},
url = {https://pub.dzne.de/record/269000},
}