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001     269000
005     20240422115859.0
024 7 _ |a 10.1007/s12268-023-2066-9
|2 doi
024 7 _ |a 0947-0867
|2 ISSN
024 7 _ |a 1868-6249
|2 ISSN
037 _ _ |a DZNE-2024-00434
082 _ _ |a 540
100 1 _ |a Fengler, Sven
|0 P:(DE-2719)2812244
|b 0
|e First author
|u dzne
245 _ _ |a Künstliche Hirngefäße zur Identifikation hirngängiger Wirkstoffe
260 _ _ |a Heidelberg
|c 2023
|b Spektrum
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
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|0 PUB:(DE-HGF)16
|s 1713774412_6652
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Due to the regulatory function of the human blood-brain barrier (BBB), optimizing brain-targeting drugs for brain-penetration is a challenge in drug discovery. Therefore, the development of in vitro assays that mimic relevant properties of the BBB are in focus to better predict drug permeability in humans. This article describes human iPSC-derived brain endothelial microvessels in perfusable multi-chip plates that provide physiological properties of the BBB in a scalable format for screening.
536 _ _ |a 899 - ohne Topic (POF4-899)
|0 G:(DE-HGF)POF4-899
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|f POF IV
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588 _ _ |a Dataset connected to CrossRef, Journals: pub.dzne.de
693 _ _ |0 EXP:(DE-2719)LAT-20190308
|5 EXP:(DE-2719)LAT-20190308
|e Laboratory Automation Technologies (CRFS-LAT) / Bonn
|x 0
700 1 _ |a Kurkowsky, Birgit
|0 P:(DE-2719)2810323
|b 1
|u dzne
700 1 _ |a Heimlich, Gerd
|b 2
700 1 _ |a Fava, Eugenio
|0 P:(DE-2719)2159508
|b 3
|u dzne
700 1 _ |a Denner, Philip
|0 P:(DE-2719)2810245
|b 4
|e Last author
|u dzne
773 _ _ |a 10.1007/s12268-023-2066-9
|g Vol. 29, no. 7, p. 766 - 767
|0 PERI:(DE-600)2203536-9
|n 7
|p 766 - 767
|t Biospektrum
|v 29
|y 2023
|x 0947-0867
856 4 _ |u https://pub.dzne.de/record/269000/files/DZNE-2024-00434.pdf
856 4 _ |u https://pub.dzne.de/record/269000/files/DZNE-2024-00434.pdf?subformat=pdfa
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909 C O |o oai:pub.dzne.de:269000
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2812244
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)2810323
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
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|6 P:(DE-2719)2159508
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)2810245
913 1 _ |a DE-HGF
|b Programmungebundene Forschung
|l ohne Programm
|1 G:(DE-HGF)POF4-890
|0 G:(DE-HGF)POF4-899
|3 G:(DE-HGF)POF4
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915 _ _ |a DEAL Springer
|0 StatID:(DE-HGF)3002
|2 StatID
|d 2023-08-22
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915 _ _ |a DEAL Springer
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915 _ _ |a DBCoverage
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915 _ _ |a DBCoverage
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920 1 _ |0 I:(DE-2719)1040190
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920 1 _ |0 I:(DE-2719)1040000
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980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1040190
980 _ _ |a I:(DE-2719)1040000
980 _ _ |a UNRESTRICTED

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